T
Teigo Asai
Researcher at University of Tokyo
Publications - 50
Citations - 1246
Teigo Asai is an academic researcher from University of Tokyo. The author has contributed to research in topics: Polyketide & Hyoscyamus niger. The author has an hindex of 21, co-authored 46 publications receiving 970 citations. Previous affiliations of Teigo Asai include Banaras Hindu University & Tohoku University.
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Journal ArticleDOI
An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii.
Yu Ming Chung,Chien Kei Wei,Da Wei Chuang,Mohamed El-Shazly,Mohamed El-Shazly,Chi Ting Hsieh,Teigo Asai,Yoshiteru Oshima,Tusty-Jiuan Hsieh,Tsong-Long Hwang,Yang Chang Wu,Fang Rong Chang +11 more
TL;DR: Among the isolates, (S)-(+)-sydonol did not only potentiate insulin-stimulated glucose consumption but also prevented lipid accumulation in 3T3-L1 adipocytes, and exhibited significant anti-inflammatory activity through inhibiting superoxide anion generation and elastase release by fMLP/CB-induced human neutrophils.
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Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers
Teigo Asai,Yu Ming Chung,Hiroaki Sakurai,Tomoji Ozeki,Fang Rong Chang,Kouwa Yamashita,Yoshiteru Oshima +6 more
TL;DR: The concomitant addition of the histone deacetylase inhibitor and the DNA methyltransferase inhibitor to the culture medium of an entomopathogenic fungus, Isaria tenuipes, greatly enhanced its secondary metabolite production and led to the isolation of tenuipyrone.
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Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides
Teigo Asai,Kento Tsukada,Satomi Ise,Naoki Shirata,Makoto Hashimoto,Isao Fujii,Katsuya Gomi,Kosuke Nakagawara,Eiichi Kodama,Yoshiteru Oshima +9 more
TL;DR: This work has developed a semi-synthetic process that combines heterologous biosynthesis and artificial diversification of fungal polyketide intermediates and demonstrated an advanced method of using biosynthetic intermediates.
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Geranylated flavanones from the secretion on the surface of the immature fruits of Paulownia tomentosa
TL;DR: Chemical investigation of the methanol extract of the viscous secretion on the surface of immature fruits of Paulownia tomentosa furnished nine geranylated flavanones, including 6-geranyl-5,7-dihydroxy-3',4'-dimethoxyflavanone, which showed potent radical scavenging effects towards DPPH radicals.
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Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton Approach
TL;DR: This study presents the first application of the VCD exciton approach to novel natural products, isolated from a filamentous fungus and cultivated in the presence of a histone deacetylase inhibitor.