N
Natalia del Pozo
Researcher at University of Deusto
Publications - 19
Citations - 590
Natalia del Pozo is an academic researcher from University of Deusto. The author has contributed to research in topics: Pancreas & Pancreatic cancer. The author has an hindex of 9, co-authored 16 publications receiving 469 citations. Previous affiliations of Natalia del Pozo include BBVA Compass & Johns Hopkins University School of Medicine.
Papers
More filters
Journal ArticleDOI
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
Isidoro Cobo,Paola Martinelli,Marta Flández,Latifa Bakiri,Mingfeng Zhang,Enrique Carrillo-de-Santa-Pau,Jinping Jia,Victor J. Sanchez-Arévalo Lobo,Diego Megías,Irene Felipe,Natalia del Pozo,Irene Millán,Liv Thommesen,Torunn Bruland,Sara H. Olson,Jill P. Smith,Kristina Schoonjans,William R. Bamlet,Gloria M. Petersen,Núria Malats,Laufey T. Amundadottir,Erwin F. Wagner,Francisco X. Real +22 more
TL;DR: An epithelial-cell-autonomous basal pre-inflammatory state in the pancreas of Nr5a2+/− mice is described that is reminiscent of the early stages of pancreatitis-induced inflammation and is conserved in histologically normal human pancreases with reduced expression of NR5A2 mRNA.
Journal ArticleDOI
Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas G12V -driven pancreatic tumourigenesis
Marta Flández,Jaroslaw Cendrowski,Marta Cañamero,Antonio Salas,Natalia del Pozo,Kristina Schoonjans,Francisco X. Real +6 more
TL;DR: A full Nr5a2 dose is required to restore pancreatic homeostasis upon damage and to suppress the KRasG12V-driven mouse pancreatic intraepithelial neoplasia progression, indicating that Nr 5a2 is a novel pancreatic tumour suppressor.
Journal ArticleDOI
Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice
Paola Martinelli,Marta Cañamero,Natalia del Pozo,Francesc Madriles,Agustín G. Zapata,Francisco X. Real +5 more
TL;DR: The data show that Gata6 is required for the complete differentiation of acinar cells through multiple transcriptional regulatory mechanisms, which suggests that GATA6 alterations may contribute to diseases of the human adult exocrine pancreas.
Journal ArticleDOI
The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice
Paola Martinelli,Francesc Madriles,Marta Cañamero,Enrique Carrillo-de Santa Pau,Natalia del Pozo,Carmen Guerra,Francisco X. Real +6 more
TL;DR: It is proposed that, in the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways.
Journal ArticleDOI
Meta-analysis of functional neuroimaging studies indicates that an increase of cognitive difficulty during executive tasks engages brain regions associated with time perception
TL;DR: This study supports the hypothesis that there exists a group of brain regions engaged both in time perception tasks and during tasks requiring cognitive effort, and brain regions associated with working memory and executive functions were found to be engaged during time estimation tasks.