Natalia V. Gulyaeva

TL;DR: A gradually developing oxidative stress was evident in the hippocampus of rats treated with Abeta(25-35) as indicated by the increase in 2-thiobarbituric acid (TBARS) reactive substances and superoxide generation, suggesting the involvement of oxidative stress in Abeta-induced neurodegeneration and a relation between memory impairment and neurodegenersation in the CA1 subfield of the hippocampus.

TL;DR: The present review focuses on the numerous experimental rodent models of depression induced by different stress factors during early life (including prenatal period) or adulthood, giving emphasis to the data on the changes of neurotrophic factors and neuroinflammatory indices in the brain.

TL;DR: The results suggest that Abeta(25-35) preferably induces impairments of spatial and non-spatial short-term (working) memory rather than long-term memory in rats.

TL;DR: A new hypothesis is suggested on the principal involvement of stress response mechanisms in the remote hippocampal damage underlying delayed dementia and depression induced by focal brain damage (e.g. post-stroke and post-traumatic) and the translational validity of this hypothesis comprising new approaches in preventing post- stroke andPost-trauma depression and dementia can be confirmed in experimental and clinical studies.

TL;DR: The articles in this issue are focused on different “hot points” in the research area of biochemical mechanisms supporting neuroplasticity.