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Natalia Wegner
Researcher at Imperial College London
Publications - 13
Citations - 2412
Natalia Wegner is an academic researcher from Imperial College London. The author has contributed to research in topics: Porphyromonas gingivalis & Citrullination. The author has an hindex of 9, co-authored 13 publications receiving 2198 citations. Previous affiliations of Natalia Wegner include University of Oxford.
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Journal ArticleDOI
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis
Natalia Wegner,Robin Wait,Aneta Sroka,Sigrun Eick,Ky-Anh Nguyen,Karin Lundberg,Andrew J Kinloch,Shauna Culshaw,Jan Potempa,Jan Potempa,Patrick J Venables +10 more
TL;DR: It is shown that P gingivalis rapidly generates citrullinated host peptides by proteolytic cleavage at Arg-X peptide bonds by arginine gingipains, followed bycitrullination of carboxy-terminal arginines by bacterial PAD.
Journal ArticleDOI
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
Natalia Wegner,Karin Lundberg,Andrew J Kinloch,Benjamin A Fisher,Vivianne Malmström,Marc Feldmann,Patrick J Venables +6 more
TL;DR: Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating evidence of pathogenic disease‐specific autoimmunity to citrullinated proteins, and both smoking and Porphyromonas gingivalis are attractive etiological agents for further investigation into the gene/environment/autoimmunities triad of RA.
Journal ArticleDOI
Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase.
Karin Lundberg,Andrew J Kinloch,Benjamin A Fisher,Natalia Wegner,Robin Wait,Peter Charles,Ted R. Mikuls,Patrick J Venables +7 more
TL;DR: The data on sequence similarity and cross-reactivity with bacterial enolase may indicate a role for bacterial infection, particularly with P gingivalis, in priming autoimmunity in a subset of patients with RA.
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Periodontitis in RA—the citrullinated enolase connection
TL;DR: The hypothesis of molecular mimicry in the etiology of RA is explored, with citrullinated enolase as the specific antigen involved.
Journal ArticleDOI
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis
Andrew J Kinloch,Karin Lundberg,Robin Wait,Natalia Wegner,Ngee Han Lim,Albert J.W. Zendman,Tore Saxne,Vivianne Malmström,Patrick J Venables +8 more
TL;DR: The results highlight the importance of synovial fluid for the expression of citrullinated autoantigens in inflammatory arthritis, and provide evidence that the alpha-enolase was citruLLinated in RA synvial fluid.