K
Karin Lundberg
Researcher at Karolinska University Hospital
Publications - 82
Citations - 8006
Karin Lundberg is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Arthritis & Rheumatoid arthritis. The author has an hindex of 32, co-authored 82 publications receiving 7117 citations. Previous affiliations of Karin Lundberg include Karolinska Institutet & Imperial College London.
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Journal ArticleDOI
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
Lars Klareskog,Patrik Stolt,Karin Lundberg,Henrik Källberg,Camilla Bengtsson,Johan Grunewald,Johan Rönnelid,Helena Erlandsson Harris,Ann-Kristin Ulfgren,Solbritt Rantapää-Dahlqvist,Anders Eklund,Leonid Padyukov,Lars Alfredsson +12 more
TL;DR: An etiology involving a specific genotype, an environmental provocation, and the induction of specific autoimmunity are suggested, all restricted to a distinct subset of RA.
Journal ArticleDOI
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis
Natalia Wegner,Robin Wait,Aneta Sroka,Sigrun Eick,Ky-Anh Nguyen,Karin Lundberg,Andrew J Kinloch,Shauna Culshaw,Jan Potempa,Jan Potempa,Patrick J Venables +10 more
TL;DR: It is shown that P gingivalis rapidly generates citrullinated host peptides by proteolytic cleavage at Arg-X peptide bonds by arginine gingipains, followed bycitrullination of carboxy-terminal arginines by bacterial PAD.
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Immunity to Citrullinated Proteins in Rheumatoid Arthritis
TL;DR: A new etiological model is proposed for ACPA-positive RA, built on MHC class II-dependent activation of adaptive immunity, which provides a new basis for molecular studies on the pathogenesis of AC PA-positive arthritis.
Journal ArticleDOI
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
Natalia Wegner,Karin Lundberg,Andrew J Kinloch,Benjamin A Fisher,Vivianne Malmström,Marc Feldmann,Patrick J Venables +6 more
TL;DR: Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating evidence of pathogenic disease‐specific autoimmunity to citrullinated proteins, and both smoking and Porphyromonas gingivalis are attractive etiological agents for further investigation into the gene/environment/autoimmunities triad of RA.
Journal ArticleDOI
Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase.
Karin Lundberg,Andrew J Kinloch,Benjamin A Fisher,Natalia Wegner,Robin Wait,Peter Charles,Ted R. Mikuls,Patrick J Venables +7 more
TL;DR: The data on sequence similarity and cross-reactivity with bacterial enolase may indicate a role for bacterial infection, particularly with P gingivalis, in priming autoimmunity in a subset of patients with RA.