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Natalia Y. Tretyakova
Researcher at University of Minnesota
Publications - 157
Citations - 5942
Natalia Y. Tretyakova is an academic researcher from University of Minnesota. The author has contributed to research in topics: DNA & Guanine. The author has an hindex of 39, co-authored 148 publications receiving 5320 citations. Previous affiliations of Natalia Y. Tretyakova include University of Texas Medical Branch & Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers
Gerd P. Pfeifer,Mikhail F. Denissenko,Magali Olivier,Natalia Y. Tretyakova,Stephen S. Hecht,Pierre Hainaut +5 more
TL;DR: The available data suggest that p53 mutations in lung cancers can be attributed to direct DNA damage from cigarette smoke carcinogens rather than to selection of pre-existing endogenous mutations.
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APOBEC3B is an enzymatic source of mutation in breast cancer
Michael B. Burns,Lela Lackey,Michael A. Carpenter,Anurag Rathore,Allison M. Land,Brandon Leonard,Eric W. Refsland,Delshanee Kotandeniya,Natalia Y. Tretyakova,Jason B. Nikas,Douglas Yee,Nuri A. Temiz,Duncan E. Donohue,Rebecca M. McDougle,William L. Brown,Emily K. Law,Reuben S. Harris +16 more
TL;DR: A model in which APOBEC3B-catalysed deamination provides a chronic source of DNA damage in breast cancers that could select TP53 inactivation is suggested to explain how some tumours evolve rapidly and manifest heterogeneity.
Journal ArticleDOI
DNA–Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes
TL;DR: The chemistry of DPC formation in cells is outlined, recent efforts to identify the cross-linked proteins by mass spectrometry are described, and various methodologies for preparing DNA strands containing structurally defined, site specific DPC lesions are discussed.
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Mass Spectrometry of Structurally Modified DNA
TL;DR: Due to their central role in chemical carcinogenesis, DNA adducts are considered the true mechanism-based biomarkers of carcinogen exposure and can be correlated to the formation of reactive intermediates available for binding to DNA and other biomolecules.
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Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene.
TL;DR: The molecular dosimetry of N-7 guanine adduct formation by these metabolites of BD in liver, lung, and kidney of B6C3F1 mice and F344 rats exposed to 0, 20, 62.5, or 625 ppm BD was studied, and it was concluded that most of the THB-Gua is formed from EBD.