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Eric W. Refsland
Researcher at University of Minnesota
Publications - 15
Citations - 2471
Eric W. Refsland is an academic researcher from University of Minnesota. The author has contributed to research in topics: APOBEC3G & Gene. The author has an hindex of 11, co-authored 15 publications receiving 2167 citations. Previous affiliations of Eric W. Refsland include National Institutes of Health.
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Journal ArticleDOI
APOBEC3B is an enzymatic source of mutation in breast cancer
Michael B. Burns,Lela Lackey,Michael A. Carpenter,Anurag Rathore,Allison M. Land,Brandon Leonard,Eric W. Refsland,Delshanee Kotandeniya,Natalia Y. Tretyakova,Jason B. Nikas,Douglas Yee,Nuri A. Temiz,Duncan E. Donohue,Rebecca M. McDougle,William L. Brown,Emily K. Law,Reuben S. Harris +16 more
TL;DR: A model in which APOBEC3B-catalysed deamination provides a chronic source of DNA damage in breast cancers that could select TP53 inactivation is suggested to explain how some tumours evolve rapidly and manifest heterogeneity.
Journal ArticleDOI
Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption
Katharine J. Bar,Michael C. Sneller,Linda Harrison,J. Shawn Justement,Edgar T. Overton,Mary E. Petrone,D. Brenda Salantes,Catherine Seamon,Benjamin Scheinfeld,Richard Kwan,Gerald H. Learn,Michael A. Proschan,Edward F. Kreider,Jana Blazkova,Mark Bardsley,Eric W. Refsland,Michael Messer,Katherine E Clarridge,Nancy B Tustin,Patrick J Madden,KaSaundra Oden,Sijy O'Dell,Bernadette Jarocki,Andrea Shiakolas,Randall Tressler,Nicole A. Doria-Rose,Robert T. Bailer,Julie E. Ledgerwood,Edmund V. Capparelli,Rebecca M. Lynch,Barney S. Graham,Susan Moir,Richard A. Koup,John R. Mascola,James A. Hoxie,Anthony S. Fauci,Pablo Tebas,Tae-Wook Chun +37 more
TL;DR: Analyses of virus populations before ART as well as before and after ART interruption showed that VRC01 exerted pressure on rebounding virus, resulting in restriction of recrudescent viruses and selection for preexisting and emerging antibody neutralization-resistant virus.
Journal ArticleDOI
Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction
Eric W. Refsland,Mark D. Stenglein,Keisuke Shindo,John S. Albin,William L. Brown,Reuben S. Harris +5 more
TL;DR: A general model in which multiple APOBEC3 proteins function together to provide a constitutive barrier to foreign genetic elements, which can be fortified by transcriptional induction is suggested.
Journal ArticleDOI
Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1
Judd F. Hultquist,Joy Lengyel,Eric W. Refsland,Rebecca S. LaRue,Lela Lackey,William L. Brown,Reuben S. Harris +6 more
TL;DR: The first comprehensive analysis of the complete, seven-member human and rhesus APOBEC3 families in HIV-1 restriction finds that one of these proteins, APOBec3G, is a potent HIV- 1 restriction factors.
Book ChapterDOI
The APOBEC3 family of retroelement restriction factors.
TL;DR: This work focuses on mechanisms of retroelement restriction by the APOBEC3 family of restriction enzymes, and considers the therapeutic benefits, as well as the possible pathological consequences, of arming cells with active DNA deaminases.