DNA–Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes
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TLDR
The chemistry of DPC formation in cells is outlined, recent efforts to identify the cross-linked proteins by mass spectrometry are described, and various methodologies for preparing DNA strands containing structurally defined, site specific DPC lesions are discussed.Abstract:
ConspectusNoncovalent DNA–protein interactions are at the heart of normal cell function. In eukaryotic cells, genomic DNA is wrapped around histone octamers to allow for chromosomal packaging in th...read more
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References
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Free radicals, antioxidants, and human disease: where are we now?
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Oxidative Nucleobase Modifications Leading to Strand Scission
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Direct cellular responses to platinum-induced DNA damage
Yongwon Jung,Stephen J. Lippard +1 more
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ChIP-seq and Beyond: new and improved methodologies to detect and characterize protein-DNA interactions
TL;DR: The latest advances in methods to detect and functionally characterize DNA-bound proteins are described, which are being used to identify variability in the functions of DNA-binding proteins across genomes and individuals.
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