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Natasha Kyprianou
Researcher at Johns Hopkins University School of Medicine
Publications - 20
Citations - 3521
Natasha Kyprianou is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Programmed cell death & Cancer. The author has an hindex of 17, co-authored 20 publications receiving 3501 citations. Previous affiliations of Natasha Kyprianou include Johns Hopkins University.
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Journal ArticleDOI
Activation of programmed cell death in the rat ventral prostate after castration.
Natasha Kyprianou,John T. Isaacs +1 more
TL;DR: Flow cytometric analysis of nuclear DNA content demonstrated that each day after castration, a subpopulation of androgen-dependent cells in rat ventral prostate fragmented all of their genomic DNA, as opposed to the whole population of cells fragmenting an increasing portion of their DNA daily.
Journal Article
Programmed cell death during regression of PC-82 human prostate cancer following androgen ablation.
TL;DR: The results suggest that androgen-dependent human prostatic cancer cells, like normal prostatic cells, retain the ability to inhibit proliferation and to activate programmed cell death in response to androgen ablation.
Journal Article
Programmed cell death during regression of the MCF-7 human breast cancer following estrogen ablation.
TL;DR: The results demonstrate that the regression of MCF-7 human mammary cancers in nude mice following estrogen ablation is due to a sequence of biochemical and morphological changes that result in both the cessation of cell proliferation and activation of programmed death or apoptosis of these MCf-7 cancer cells.
Journal ArticleDOI
Expression of transforming growth factor-β in the rat ventral prostate during castration-induced programmed cell death
Natasha Kyprianou,John T. Isaacs +1 more
TL;DR: Androgen administration to 4-day castrated rats led to a marked decrease in TGF beta mRNA to a level comparable to its constitutive expression obtained in the intact control animals, indicating that expression of TGFbeta in the rat ventral prostate is under negative androgenic regulation.
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Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration.
TL;DR: Test the cause versus effect nature of DNA fragmentation in the programmed death of androgen dependent prostatic cells following castration found changes in DNA metabolism must be the consequences of cell death but instead are early causal events in an active process of programmed cell death.