Showing papers by "Nathan C. Gianneschi published in 2005"
TL;DR: The course of investigations in this area is described, beginning with the development of a chemical tool kit of building blocks consisting of multiple metals and ligands, which can be rationally mixed and matched to provide structures with a wide range of properties.
Abstract: The weak-link approach (WLA) to supramolecular assemblies allows for the design of multimetallic two- and three-dimensional arrays, host-guest architectures, sensors, catalysts, switches, and signal amplification devices. This Account describes the course of our investigations in this area beginning with the development of a chemical tool kit of building blocks consisting of multiple metals and ligands. These building blocks can be rationally mixed and matched to provide structures with a wide range of properties that have been used to develop functional supramolecular architectures, including chemical sensors and allosteric catalysts.
510 citations
TL;DR: This three-part detection scheme involving analyte binding, allosteric catalyst activation, and signal transduction represents a new approach to small-molecule detection.
Abstract: The design of a supramolecular allosteric catalyst system for catalytic signal amplification and detection is presented. The catalyst was switched “on” by the introduction of an analyte that also behaves as an allosteric activator. Concentrations of Cl- ions as low as 800 nM were catalytically amplified and detected. The signal was transduced via a pH-sensitive fluorescent probe and observed visually using a laboratory, handheld UV lamp and by spectrophotometry. Furthermore, the allosteric effect was quantified using gas chromatography for a range of Cl- concentrations. This three-part detection scheme involving analyte binding, allosteric catalyst activation, and signal transduction represents a new approach to small-molecule detection.
172 citations
Patent•
18 Aug 2005TL;DR: In this article, the coordination complexes having at least two structural conformations are disclosed, and methods of detecting an analyte using the coordination complex are also disclosed, including methods for detecting analyte detection using coordination complexes with allosteric effectors.
Abstract: Coordination complexes having at least two structural conformations are disclosed. The coordination complexes contain at least one metal center and at least one hemi-labile ligand, and change structural conformations due to thepresence or absence of allosteric effectors. Methods of detecting an analyte using the coordination complexes are also disclosed.
3 citations
Patent•
18 Aug 2005
TL;DR: In this article, the authors propose a method for detecting allosteriques in complexes of coordination presentant au moins deux conformations structurales, and concerne egalement des methodes de detection d'un analyte a l'aide des complexes de coordination.
Abstract: L'invention concerne des complexes de coordination presentant au moins deux conformations structurales. Les complexes de coordination contiennent au moins un centre metallique et au moins un ligand hemilabile, et changent de conformations structurales du fait de la presence ou de l'absence d'effecteurs allosteriques. L'invention concerne egalement des methodes de detection d'un analyte a l'aide des complexes de coordination.