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Nathaniel D. Denkers
Researcher at Colorado State University
Publications - 18
Citations - 733
Nathaniel D. Denkers is an academic researcher from Colorado State University. The author has contributed to research in topics: Chronic wasting disease & Transmissible spongiform encephalopathy. The author has an hindex of 13, co-authored 17 publications receiving 564 citations.
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Journal ArticleDOI
Rapid Antemortem Detection of CWD Prions in Deer Saliva
Davin M. Henderson,Matteo Manca,Matteo Manca,Nicholas J. Haley,Nathaniel D. Denkers,Amy V. Nalls,Candace K. Mathiason,Byron Caughey,Edward A. Hoover +8 more
TL;DR: The modified RT-QuIC analysis described represents a non-invasive, rapid ante-mortem detection of prions in complex biologic fluids, excreta, or environmental samples as a tool for exploring prion trafficking, peripheralization, and dissemination.
Journal ArticleDOI
Quantitative assessment of prion infectivity in tissues and body fluids by real-time quaking-induced conversion.
Davin M. Henderson,Kristen A. Davenport,Nicholas J. Haley,Nathaniel D. Denkers,Candace K. Mathiason,Edward A. Hoover +5 more
TL;DR: Samples from deer infected with chronic wasting disease in RT-QuIC were used to show that serial dilution of prion seed was linearly related to the rate of amyloid formation over a range of 10(-3) to 10(-8) µg.
Journal ArticleDOI
Longitudinal detection of prion shedding in saliva and urine by chronic wasting disease-infected deer by real-time quaking-induced conversion.
Davin M. Henderson,Nathaniel D. Denkers,Clare E. Hoover,Nina C. Garbino,Candace K. Mathiason,Edward A. Hoover +5 more
TL;DR: An in vitro amplification assay is used to show that infectious doses of CWD prions are in fact shed throughout the multiyear disease course in deer, an important advance in assessing the risks posed by shed C WD prions to animals as well as humans.
Journal ArticleDOI
Aerosol Transmission of Chronic Wasting Disease in White-Tailed Deer
Nathaniel D. Denkers,Jeanette Hayes-Klug,Kelly Anderson,Davis M. Seelig,Nicholas J. Haley,Sallie J. Dahmes,David A. Osborn,Karl V. Miller,Robert J. Warren,Candace K. Mathiason,Edward A. Hoover +10 more
TL;DR: Aerosol transmission of CWD to deer with a prion dose >20-fold lower than that used in previous oral inoculations is demonstrated to address the question in the native cervid host.
Journal ArticleDOI
Mucosal immunization with an attenuated Salmonella vaccine partially protects white-tailed deer from chronic wasting disease
Fernando Goni,Candace K. Mathiason,Lucía Yim,Kinlung Wong,Jeanette Hayes-Klug,Amy V. Nalls,Daniel Peyser,Veronica Estevez,Nathaniel D. Denkers,Jinfeng Xu,David A. Osborn,Karl V. Miller,Robert J. Warren,David R. Brown,José A. Chabalgoity,Edward A. Hoover,Thomas Wisniewski +16 more
TL;DR: This study documents the first partially successful vaccination for a prion disease in a species naturally at risk of Chronic wasting disease, and shows that immunoglobulins from this vaccinate react to PrP(CWD).