N
Nathaniel R. Campbell
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 40
Citations - 2412
Nathaniel R. Campbell is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 21, co-authored 39 publications receiving 1838 citations. Previous affiliations of Nathaniel R. Campbell include Kettering University & Brigham and Women's Hospital.
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Journal ArticleDOI
Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice
Dipankar Pramanik,Nathaniel R. Campbell,Collins Karikari,Raghu R. Chivukula,Oliver A. Kent,Joshua T. Mendell,Anirban Maitra +6 more
TL;DR: The nanovector is a platform with potential broad applicability in systemic miRNA delivery to cancer cells and was confirmed in treated xenografts by significant upregulation of the corresponding miRNA and significant decreases in specific miRNA targets.
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Regenerative lineages and immune-mediated pruning in lung cancer metastasis
Ashley M. Laughney,Jing Hu,Nathaniel R. Campbell,Nathaniel R. Campbell,Samuel F. Bakhoum,Manu Setty,Vincent-Philippe Lavallée,Yubin Xie,Yubin Xie,Ignas Masilionis,Ambrose J. Carr,Sanjay Kottapalli,Viola Allaj,Marissa Mattar,Natasha Rekhtman,Joao B. Xavier,Linas Mazutis,John T. Poirier,Charles M. Rudin,Dana Pe'er,Joan Massagué +20 more
TL;DR: Human primary lung adenocarcinomas are characterized by the emergence of regenerative cell types, typically seen in response to lung injury, and by striking infidelity among transcription factors specifying most alveolar and bronchial epithelial lineages.
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Adipocyte-Derived Lipids Mediate Melanoma Progression via FATP Proteins.
Maomao Zhang,Julie Di Martino,Robert L. Bowman,Nathaniel R. Campbell,Nathaniel R. Campbell,Sanjeethan C. Baksh,Theresa Simon-Vermot,Isabella S. Kim,Pearce Haldeman,Chandrani Mondal,Vladimir Yong-Gonzales,Mohsen Abu-Akeel,Taha Merghoub,Drew R. Jones,Xiphias Ge Zhu,Arshi Arora,Charlotte E. Ariyan,Kıvanç Birsoy,Jedd D. Wolchok,Katherine S. Panageas,Travis J. Hollmann,Jose Javier Bravo-Cordero,Richard M. White +22 more
TL;DR: It is demonstrated that stromal adipocytes are donors of lipids that mediate melanoma progression and represent a new target aimed at interrupting adipocyte-melanoma cross-talk, a novel microenvironmental therapeutic target.
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miR-181c Regulates the Mitochondrial Genome, Bioenergetics, and Propensity for Heart Failure In Vivo
Samarjit Das,Djahida Bedja,Djahida Bedja,Nathaniel R. Campbell,Brittany Dunkerly,Brittany Dunkerly,Venugopal Chenna,Anirban Maitra,Charles Steenbergen +8 more
TL;DR: For the first time, this study shows that miRNA delivered to the heart in-vivo can lead to cardiac dysfunction by regulating mitochondrial genes.
Journal ArticleDOI
Notch signaling pathway targeted therapy suppresses tumor progression and metastatic spread in pancreatic cancer
Shinichi Yabuuchi,Shweta G. Pai,Nathaniel R. Campbell,Roeland F. de Wilde,Elizabeth De Oliveira,Preethi Korangath,Mirte M. Streppel,Zeshaan A. Rasheed,Manuel Hidalgo,Anirban Maitra,N. V. Rajeshkumar +10 more
TL;DR: Preclinical data suggest that PF-03084014 has greater anti-tumor activity in combination with gemcitabine in Pda and provides rationale for further investigation of this combination in PDA.