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Ignas Masilionis
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 29
Citations - 819
Ignas Masilionis is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Biology & Cancer. The author has an hindex of 6, co-authored 13 publications receiving 280 citations. Previous affiliations of Ignas Masilionis include Malmö University & Kettering University.
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Journal ArticleDOI
Regenerative lineages and immune-mediated pruning in lung cancer metastasis
Ashley M. Laughney,Jing Hu,Nathaniel R. Campbell,Nathaniel R. Campbell,Samuel F. Bakhoum,Manu Setty,Vincent-Philippe Lavallée,Yubin Xie,Yubin Xie,Ignas Masilionis,Ambrose J. Carr,Sanjay Kottapalli,Viola Allaj,Marissa Mattar,Natasha Rekhtman,Joao B. Xavier,Linas Mazutis,John T. Poirier,Charles M. Rudin,Dana Pe'er,Joan Massagué +20 more
TL;DR: Human primary lung adenocarcinomas are characterized by the emergence of regenerative cell types, typically seen in response to lung injury, and by striking infidelity among transcription factors specifying most alveolar and bronchial epithelial lineages.
Journal ArticleDOI
Regenerative potential of prostate luminal cells revealed by single-cell analysis.
Wouter R. Karthaus,Matan Hofree,Danielle Choi,Eliot Linton,Mesruh Turkekul,Alborz Bejnood,Brett S. Carver,Anuradha Gopalan,Wassim Abida,Vincent P. Laudone,Moshe Biton,Ojasvi Chaudhary,Tianhao Xu,Ignas Masilionis,Katia Manova,Linas Mazutis,Dana Pe'er,Aviv Regev,Aviv Regev,Charles L. Sawyers,Charles L. Sawyers +20 more
TL;DR: It is proposed that prostate regeneration is driven by nearly all persisting luminal cells, not just by rare stem cells, and analysis of human prostate tissue revealed similar differentiated and stemlike luminal subpopulations that likewise acquire enhanced regenerative potential after androgen ablation.
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L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer
Karuna Ganesh,Harihar Basnet,Yasemin Kaygusuz,Ashley M. Laughney,Ashley M. Laughney,Lan He,Roshan Sharma,Roshan Sharma,Kevin P. O’Rourke,Kevin P. O’Rourke,Vincent P. Reuter,Yun-Han Huang,Yun-Han Huang,Mesruh Turkekul,Ekrem Emrah Er,Ekrem Emrah Er,Ignas Masilionis,Katia Manova-Todorova,Martin R. Weiser,Leonard B. Saltz,Julio Garcia-Aguilar,Richard Koche,Scott W. Lowe,Dana Pe'er,Jinru Shia,Joan Massagué +25 more
TL;DR: It is shown that L1CAM+ cells in human colorectal cancer (CRC) have metastasis-initiating capacity, and their relationship to tissue regeneration is defined, which emerges in regenerative intestinal cells when epithelial integrity is lost.
Journal ArticleDOI
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Joseph M. Chan,Álvaro Quintanal-Villalonga,Vianne R. Gao,Vianne R. Gao,Yubin Xie,Yubin Xie,Viola Allaj,Ojasvi Chaudhary,Ignas Masilionis,Jacklynn V. Egger,Andrew Chow,Thomas Walle,Marissa Mattar,Dig Vijay Kumar Yarlagadda,James L. Wang,Fathema Uddin,Michael Offin,Metamia Ciampricotti,Besnik Qeriqi,Amber Bahr,Elisa de Stanchina,Umesh Bhanot,W. Victoria Lai,Matthew J. Bott,David R. Jones,Arvin Ruiz,Marina K. Baine,Yanyun Li,Natasha Rekhtman,John T. Poirier,Tal Nawy,Triparna Sen,Triparna Sen,Linas Mazutis,Travis J. Hollmann,Dana Pe'er,Charles M. Rudin,Charles M. Rudin +37 more
TL;DR: In this article, the heterogeneity of small cell lung cancer (SCLC) is defined by differential expression of ASCL1, NEUROD1, and POU2F3.
Journal ArticleDOI
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Joseph M. Chan,Samir Zaidi,Jillian R. Love,Jimmy L. Zhao,Manu Setty,Kristine M. Wadosky,Anuradha Gopalan,Zi-Ning Choo,Sitara Persad,Jungmin Choi,Justin R. LaClair,K. E. Lawrence,Ojasvi Chaudhary,Tianhao Xu,Ignas Masilionis,Irina Linkov,Shangqian Wang,Cindy Lee,Afsar Barlas,Michael J. Morris,Linas Mazutis,Ronan Chaligne,Yu Chen,David W. Goodrich,Wouter R. Karthaus,Dana Pe'er,Charles L. Sawyers +26 more
TL;DR: It is found that plasticity initiates in an epithelial population defined by mixed luminal-basal phenotype and that it depends on elevated JAK and FGFR activity.