N
Navjot Shah
Researcher at Medical University of South Carolina
Publications - 19
Citations - 915
Navjot Shah is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Withaferin A & Withania somnifera. The author has an hindex of 13, co-authored 19 publications receiving 745 citations. Previous affiliations of Navjot Shah include Guru Nanak Dev University & Queen Victoria Hospital.
Papers
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Journal ArticleDOI
Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells
Arpita Konar,Navjot Shah,Rumani Singh,Nishant Saxena,Sunil C. Kaul,Renu Wadhwa,Mahendra K. Thakur +6 more
TL;DR: It is suggested that besides cholinergic blockade, scopolamine-induced memory loss may be associated with oxidative stress and Ashwagandha i-Extract, and withanone may serve as potential preventive and therapeutic agents for neurodegenerative disorders and hence warrant further molecular analyses.
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Selective Killing of Cancer Cells by Ashwagandha Leaf Extract and Its Component Withanone Involves ROS Signaling
Nashi Widodo,Didik Priyandoko,Didik Priyandoko,Navjot Shah,Navjot Shah,Renu Wadhwa,Sunil C. Kaul +6 more
TL;DR: Ashwagandha leaf extract and Withanone cause selective killing of cancer cells by induction of ROS-signaling and hence are potential reagents that could be recruited for ROS-mediated cancer chemotherapy.
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Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.
Kirti Vaishnavi,Nishant Saxena,Nishant Saxena,Navjot Shah,Navjot Shah,Rumani Singh,Rumani Singh,Kavyashree Manjunath,Muthukumarasamy Uthayakumar,Shankar Prasad Kanaujia,Sunil C. Kaul,Kanagaraj Sekar,Renu Wadhwa +12 more
TL;DR: It is demonstrated that Wi-A that binds strongly to the selected targets acts as a strong cytotoxic agent both for normal and cancer cells, and Wi-N, on the other hand, has a weak binding to the targets; it showed milder cytotoxicity towards cancer cells and was safe for normal cells.
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Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: Combinational approach for enhanced differentiation
TL;DR: The data suggest that the i‐Extract and its components have the potential to induce senescence‐like growth arrest and differentiation in glioma cells and led us to formulate a unique combination formula of i-Extract components that caused enhanced differentiation of glial cells.
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Water Extract of Ashwagandha Leaves Has Anticancer Activity: Identification of an Active Component and Its Mechanism of Action
Renu Wadhwa,Rumani Singh,Ran Gao,Navjot Shah,Nashi Widodo,Tomoko Nakamoto,Yoshiyuki Ishida,Keiji Terao,Sunil C. Kaul +8 more
TL;DR: The first molecular evidence that the ASH-WEX and TEG have selective cancer cell growth arrest activity is provided and hence may offer natural and economic resources for anticancer medicine is provided.