S
Sunil C. Kaul
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 317
Citations - 12020
Sunil C. Kaul is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 59, co-authored 307 publications receiving 10780 citations. Previous affiliations of Sunil C. Kaul include International Christian University & Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
Teruaki Nomura,Matiullah Khan,Sunil C. Kaul,Haidong Dong,Renu Wadhwa,Clemencia Colmenares,Isao Kohno,Shunsuke Ishii +7 more
TL;DR: The involvement of c-Ski in theHDAC complex indicates that the function of the HDAC complex is important for oncogenesis and that Ski is required for the transcriptional repression mediated by this complex.
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An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where?
TL;DR: Information is compiled and reviewed on the multiple sites and functions of mortalin in different organisms and the relevance of its differential distributions and functions in normal and immortal cell phenotypes is discussed.
Journal Article
Selective Toxicity of MKT-077 to Cancer Cells Is Mediated by Its Binding to the hsp70 Family Protein mot-2 and Reactivation of p53 Function
Renu Wadhwa,Takashi Sugihara,Akiko Yoshida,Hitoshi Nomura,Roger R. Reddel,Richard J. Simpson,Hiroshi Maruta,Sunil C. Kaul +7 more
TL;DR: It is reported that MKT-077 binds to an hsp70 family member, mortalin (mot-2), and abrogates its interactions with the tumor suppressor protein, p53, and induced release of wild-type p53 from cytoplasmically sequestered p53-Mot-2 complexes and rescued its transcriptional activation function.
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Upregulation of mortalin/mthsp70/Grp75 contributes to human carcinogenesis.
Renu Wadhwa,Syuichi Takano,Kamaljit Kaur,Custer C. Deocaris,Custer C. Deocaris,Olivia M. Pereira-Smith,Roger R. Reddel,Sunil C. Kaul +7 more
TL;DR: The study demonstrates that upregulation of mortalin contributes significantly to tumorigenesis, and thus is a good candidate target for cancer therapy.
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Three faces of mortalin: a housekeeper, guardian and killer.
TL;DR: Mortalin was first cloned as a mortality factor that existed in the cytoplasmic fractions of normal, but not in immortal, mouse fibroblasts and was proved to be an attractive target for cancer therapy.