Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.
Kirti Vaishnavi,Nishant Saxena,Nishant Saxena,Navjot Shah,Navjot Shah,Rumani Singh,Rumani Singh,Kavyashree Manjunath,Muthukumarasamy Uthayakumar,Shankar Prasad Kanaujia,Sunil C. Kaul,Kanagaraj Sekar,Renu Wadhwa +12 more
TLDR
It is demonstrated that Wi-A that binds strongly to the selected targets acts as a strong cytotoxic agent both for normal and cancer cells, and Wi-N, on the other hand, has a weak binding to the targets; it showed milder cytotoxicity towards cancer cells and was safe for normal cells.Citations
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Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Behrouz Hassannia,Bartosz Wiernicki,Irina Ingold,Feng Qu,Simon Van Herck,Yulia Y. Tyurina,Hülya Bayır,Behnaz Ahangarian Abhari,José Pedro Friedmann Angeli,Sze Men Choi,Eline Meul,Karen Heyninck,Ken Declerck,Chandra Sekhar Chirumamilla,Maija Lahtela-Kakkonen,Guy Van Camp,Dmitri V. Krysko,Paul G Ekert,Simone Fulda,Simone Fulda,Bruno G. De Geest,Marcus Conrad,Valerian E. Kagan,Wim Vanden Berghe,Wim Vanden Berghe,Peter Vandenabeele,Tom Vanden Berghe +26 more
TL;DR: Withaferin A (WA) is identified as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism that might explain the superior efficacy of WA as compared with etoposide or cisplatin in killing a heterogeneous panel of high-risk Neuroblastoma cells, and in suppressing the growth and relapse rate of neuroblastomas xenografts.
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Pharmacologic overview of Withania somnifera, the Indian Ginseng
TL;DR: Withania somnifera is a potential drug candidate to treat various clinical conditions, particularly related to the nervous system, and the mechanisms of action and potential therapeutic applications of the plant and its active constituents are discussed.
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Withaferin-A—A Natural Anticancer Agent with Pleitropic Mechanisms of Action
In-Chul Lee,Bu Young Choi +1 more
TL;DR: This review highlights the mechanistic aspects underlying anticancer effects of withaferin-A, which suppresses experimentally induced carcinogenesis, largely by virtue of its potent anti-oxidative, anti-inflammatory, pro-proliferative and apoptosis-inducing properties.
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Chemo- and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review
Alexey Lagunin,Rajesh Kumar Goel,Dinesh Y. Gawande,Priynka Pahwa,Tatyana A. Gloriozova,Alexander V. Dmitriev,Sergey Ivanov,A. V. Rudik,Varvara I. Konova,Pavel V. Pogodin,D. S. Druzhilovsky,Vladimir Poroikov +11 more
TL;DR: This review contains a practical example of the application of combined chemo- and bioinformatics methods to study pleiotropic therapeutic effects of 50 medicinal plants from Traditional Indian Medicine.
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Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases
TL;DR: Various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury are summarized.
References
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WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
TL;DR: In this article, an improved two-hybrid system was employed to isolate human genes encoding Cdk-interacting proteins (Cips) and found that CIP1 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk2.
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Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
TL;DR: The crystal structure of a complex containing the core domain of human p53 and a DNA binding site provides a framework for understanding how mutations inactivate it, and supports the hypothesis that DNA binding is critical for the biological activity of p53.
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The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
TL;DR: A possible role of the Nrf2-antioxidant response element transcriptional pathway in neuroprotection and the nature of this pathway and the mechanisms by which Keap1 acts to repress NRF2 activity are the topics of discussion in this minireview.
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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
TL;DR: It is shown that p21 directly inhibits PCNA-dependent DNA replication in the absence of a cyclin/CDK, and blocks the ability of PCNA to activateDNA polymerase δ, the principal replicative DNA polymerase.