Nazif Maqani

TL;DR: The identification of multiple novel effectors of yeast chronological lifespan will greatly aid in the elucidation of mechanisms that cells and organisms utilize in slowing down the aging process.

TL;DR: A complex system for globally regulating repair activity in vivo by controlling turnover of Rad4 is suggested, and genetic analysis uncovered new interactions between NEF4 and Rad23, a repair factor that links repair to proteasome function.

TL;DR: It is concluded that CR maximizes Snf1 activity throughout and beyond the diauxic shift, thus optimizing the coordination of nucleocytosolic acetyl-CoA production with massive reorganization of the transcriptome and respiratory metabolism.

TL;DR: It is shown that in contrast to previous reports, Sir2 is not stimulated by CR to strengthen silencing of multiple reporter genes in the rDNA of S. cerevisiae, and CR does modestly reduce the frequency of rDNA recombination, although in a SIR2‐independent manner.

TL;DR: This study determined that isonicotinamide (INAM) stimulates Sir2 through an additional mechanism in vivo, which involves elevation of the intracellular NAD+ concentration, and provides evidence suggesting that INAM influences the expression of multiple NAD+ biosynthesis and salvage pathways to promote homeostasis during stationary phase.