s, or keywords if they used Heck-type chemistry in their syntheses, because it became one of basic tools of organic preparations, a natural way to

http://aether.cmi.ua.ac.be/artikels/Artikels%20Gitte/Artikels/Reviews/Heck%20reactie%20Beletskaya%20%20Chem.%20Rev.%20003009.pdf

The heck reaction as a sharpening stone of palladium catalysis.

Microwave assisted organic synthesis-a review

Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis

The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an increased risk of cardiovascular disease and diabetes. The metabolic syndrome can be d...

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

https://endoinfo.ru/guidelines/ata_hypothyroidism_adults.pdf

Clinical Practice Guidelines for Hypothyroidism in Adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association

Atherosclerotic cardiovascular disease is a major problem despite the availability of drugs that influence major risk factors. New treatments are needed, and there is growing interest in therapies that may have multiple actions. Thyroid hormone modulates several cardiovascular risk factors and delays atherosclerosis progression in humans. However, use of thyroid hormone is limited by side effects, especially in the heart. To overcome this limitation, pharmacologically selective thyromimetics that mimic metabolic effects of thyroid hormone and bypass side effects are under development. In animal models, such thyromimetics have been shown to stimulate cholesterol elimination through LDL and HDL pathways and decrease body weight without eliciting side effects. We report here studies on a selective thyromimetic [KB2115; (3-[[3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-phenoxy]-phenyl]-amino]-3-oxopropanoic acid)] in humans. In moderately overweight and hypercholesterolemic subjects KB2115 was found to be safe and well tolerated and elicited up to a 40% lowering of total and LDL cholesterol after 14 days of treatment. Bile acid synthesis was stimulated without evidence of increased cholesterol production, indicating that KB2115 induced net cholesterol excretion. KB2115 did not provoke detectable effects on the heart, suggesting that the pharmacological selectivity observed in animal models translates to humans. Thus, selective thyromimetics deserve further study as agents to treat dyslipidemia and other risk factors for atherosclerosis.

https://www.pnas.org/content/pnas/105/2/663.full.pdf

The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans

Architecture that facilitates validation of a data mapping of data from a data source to a data target. There is included a signature generation component that generates a source signature of all or a portion of the data source and a target signature of all or a corresponding portion of the data target, and a sampling component that obtains a sample of the source data a corresponding sample of the target data. The data signatures and data samples are compared respectively and processed with a processing component to determine the status of the validation process.

Data validation using signatures and sampling

The distinct conformational preferences observed for the pentofuranosyl moieties in various 3'-substituted 2',3'-dideoxythymidine derivatives are closely related to the strength of the 3'-gauche effect, which is directly dictated by the electronegativity of the 3'-substituent. The efficiency of the 3'-gauche effect can now be quantitatively calculated with the help of simple linear calibration curves that correlate the gauche effect enthalpy AH^^") and the group electronegativity (x) of the 3'-substituent.

http://www.boc.uu.se/boc14www/publications/231.pdf

How Does the Electronegativity of the Substituent Dictate the Strength of the Gauche Effect

Design and fast synthesis of C-terminal duplicated potent C2-symmetric P1/P1'-modified HIV-1 protease inhibitors

Design and Fast Synthesis of C-Terminal Duplicated Potent C2-Symmetric P1/P1‘-Modified HIV-1 Protease Inhibitors

Data usage of a messaging application is mitigated based on a location of the application on the display screen or a mode of a device. If the location of the application is in the foreground of the display, presence update information of a contact is periodically received or requested. If the application is in the background of the display longer than a predetermined interval, the presence update information of the contact is stopped. In some embodiments, if the device is in an OFF or a SUSPEND mode, contact presence updates are not received. When the device is in an ON mode or state, the presence updates are received or requested from a server or presence agent.

Neeraj Garg

Papers

The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans

Data validation using signatures and sampling

How Does the Electronegativity of the Substituent Dictate the Strength of the Gauche Effect

Design and Fast Synthesis of C-Terminal Duplicated Potent C2-Symmetric P1/P1‘-Modified HIV-1 Protease Inhibitors

Mitigating data usage in messaging applications