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Neil F. Box
Researcher at University of Colorado Denver
Publications - 58
Citations - 4324
Neil F. Box is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Melanoma & Genotype. The author has an hindex of 30, co-authored 58 publications receiving 4086 citations. Previous affiliations of Neil F. Box include University of Queensland & United States Department of Veterans Affairs.
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Journal ArticleDOI
Melanocortin-1 Receptor Polymorphisms and Risk of Melanoma: Is the Association Explained Solely by Pigmentation Phenotype?
James S. Palmer,James S. Palmer,David L. Duffy,Neil F. Box,Joanne F. Aitken,Louise O'Gorman,Adèle C. Green,Nicholas K. Hayward,Nicholas G. Martin,Richard A. Sturm +9 more
TL;DR: It is concluded that the effect that MC1R variant alleles have on CMM is partly mediated via determination of pigmentation phenotype and that these alleles may also negate the protection normally afforded by darker skin coloring in some members of this white population.
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Human pigmentation genes: identification, structure and consequences of polymorphic variation
TL;DR: Functional correlation of MC1R alleles with skin and hair colour provides evidence that this receptor molecule is a principle component underlying normal human pigment variation.
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Characterization of Melanocyte Stimulating Hormone Receptor Variant Alleles in Twins with Red Hair
TL;DR: Genotyping 25 red haired and 62 non-red Caucasians and dizygotic twin pairs discordant for red hair colour indicates that the MSHR gene cannot be solely responsible for the red hair phenotype, and it is likely that additional modifier genes exist, making variance in the MS HR gene necessary but not always sufficient, for redhair production.
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MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations
Neil F. Box,David L. Duffy,Wei Chen,Mitchell S. Stark,Nicholas G. Martin,Richard A. Sturm,Nicholas K. Hayward +6 more
TL;DR: The impact of MC1R variants on risk of melanoma was mediated largely through the action of three common alleles, Arg151Cys, Arg160Trp, and Asp294His, that have previously been associated with red hair, fair skin, and skin sensitivity to ultraviolet light.
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Interactive effects of MC1R and OCA2 on melanoma risk phenotypes
David L. Duffy,Neil F. Box,Wei Chen,James S. Palmer,Grant W. Montgomery,Michael R. James,Nicholas K. Hayward,Nicholas G. Martin,Richard A. Sturm +8 more
TL;DR: Amongst individuals with a R/R genotype (but not R/r), those who also had brown eyes had a mole count twice that of those with blue eyes, which suggests that other OCA2 polymorphisms influence mole count and remain to be described.