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Neil Michael Otto
Researcher at University of Minnesota
Publications - 12
Citations - 4265
Neil Michael Otto is an academic researcher from University of Minnesota. The author has contributed to research in topics: Autophagy & Phosphorylation. The author has an hindex of 7, co-authored 10 publications receiving 3728 citations.
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Journal ArticleDOI
mTOR regulation of autophagy
TL;DR: This review discusses the recent advances in understanding of the mechanism by which TOR regulates autophagy with focus on mammalian TOR (mTOR) and its regulation of the Autophagy machinery.
Journal ArticleDOI
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung,Chang Bong Jun,Seung Hyun Ro,Young Mi Kim,Neil Michael Otto,Jing Cao,Mondira Kundu,Do Hyung Kim +7 more
TL;DR: It is identified that mTOR phosphorylates a mammalian homologue of Atg13 and the mammalian Atg1 homologues ULK1 and ULK2, which demonstrate that the ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling.
Journal ArticleDOI
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
Ji Man Park,Chang Hwa Jung,Minchul Seo,Neil Michael Otto,Douglas Grunwald,Kwan Hyun Kim,Branden S. Moriarity,Young Mi Kim,Colby G. Starker,Richard Seonghun Nho,Daniel F. Voytas,Do Hyung Kim +11 more
TL;DR: A key molecular event is defined for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1, and hierarchical relations between the ULK 1 activation and other autophagy proteins involved in phagophore formation are demonstrated.
Journal ArticleDOI
ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.
TL;DR: It is found that ULK1 inhibits the kinase activity of mTORC1 and cell proliferation and is important to coordinately regulate cell growth and autophagy with optimized utilization of cellular energy.
Journal ArticleDOI
ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction.
Ji Man Park,Minchul Seo,Chang Hwa Jung,Douglas Grunwald,Matthew D. Stone,Neil Michael Otto,Erik A. Toso,Yeseul Ahn,Michael Kyba,Timothy J. Griffin,LeeAnn Higgins,Do Hyung Kim +11 more
TL;DR: It is demonstrated that BECN1 Ser30 is a ULK1 target site whose phosphorylation activates the ATG14-containing PIK3C3 complex and stimulates autophagosome formation in response to amino acid starvation, hypoxia, and MTORC1 inhibition.