K
Kwan Hyun Kim
Researcher at University of Minnesota
Publications - 22
Citations - 1023
Kwan Hyun Kim is an academic researcher from University of Minnesota. The author has contributed to research in topics: Tube formation & mTORC1. The author has an hindex of 14, co-authored 22 publications receiving 831 citations. Previous affiliations of Kwan Hyun Kim include University of South Florida & Kyung Hee University.
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Journal ArticleDOI
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
Ji Man Park,Chang Hwa Jung,Minchul Seo,Neil Michael Otto,Douglas Grunwald,Kwan Hyun Kim,Branden S. Moriarity,Young Mi Kim,Colby G. Starker,Richard Seonghun Nho,Daniel F. Voytas,Do Hyung Kim +11 more
TL;DR: A key molecular event is defined for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1, and hierarchical relations between the ULK 1 activation and other autophagy proteins involved in phagophore formation are demonstrated.
Journal ArticleDOI
Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities
Jung-Min Choi,Eun Ok Lee,Hyo-Jung Lee,Kwan Hyun Kim,Kyoo Seok Ahn,Bum Sang Shim,Nam Il Kim,Myoung Chong Song,Nam-In Baek,Sung Hoon Kim +9 more
TL;DR: Results support a potential antiangiogenic action of campesterol via an inhibition of endothelial cell proliferation and capillary differentiation in humans and chick chorioallantoic membrane in vivo.
Journal ArticleDOI
Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis
Cristina W. Nogueira,Cristina W. Nogueira,Cristina W. Nogueira,Kwan Hyun Kim,Hyeran Sung,Kim H. T. Paraiso,Jan-Hermen Dannenberg,Jan-Hermen Dannenberg,Marcus Bosenberg,Marcus Bosenberg,Lynda Chin,Minjung Kim,Minjung Kim +12 more
TL;DR: It is shown that HRAS activation cooperates with Pten+/− and Ink4a/Arf−/− to increase melanoma penetrance and promote metastasis, and Pten inactivation can drive the genesis and promote the metastatic progression of RAS activated Ink4-a-Arf deficient melanomas.
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Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes
Seung Hyun Ro,Chang Hwa Jung,Wendy S. Hahn,Xin Xu,Young Mi Kim,Young Sung Yun,Ji Man Park,Kwan Hyun Kim,Minchul Seo,Tae Youl Ha,Edgar A. Arriaga,David A. Bernlohr,Do Hyung Kim +12 more
TL;DR: It is suggested that ULK1, albeit its important autophagic role, regulates lipid metabolism and glucose uptake in adipocytes distinctly from other autophagy proteins.
Journal ArticleDOI
In vivo Anti-Cancer Activity of Korean Angelica Gigas and its Major Pyranocoumarin Decursin
Hyo-Jeong Lee,Hyo-Jung Lee,Eun Ok Lee,Jae-Ho Lee,Kuen Sung Lee,Kwan Hyun Kim,Sung Hoon Kim,Sung Hoon Kim,Junxuan Lu +8 more
TL;DR: The AGN extract possessed significant in vivo anti-cancer activity, but decursin and DA only contributed moderately to that activity, most likely through decurs inol.