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Nelson Dusetti
Researcher at Aix-Marseille University
Publications - 155
Citations - 6173
Nelson Dusetti is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 40, co-authored 129 publications receiving 5203 citations. Previous affiliations of Nelson Dusetti include University of Buenos Aires & French Institute of Health and Medical Research.
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Journal ArticleDOI
MicroRNAs in pancreatic ductal adenocarcinoma: new diagnostic and therapeutic clues.
TL;DR: Recent knowledge about miRNA expression in pancreatic ductal adenocarcinoma is summarized, their possible molecular implications are discussed, and the possible repercussion of these findings in terms of diagnosis and treatment of this disease is discussed.
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TP53INP1 overexpression in prostate cancer correlates with poor prognostic factors and is predictive of biological cancer relapse.
Sophie Giusiano,Stéphane Garcia,Claudia Andrieu,Nelson Dusetti,Cyrille Bastide,Martin E. Gleave,Colette Taranger-Charpin,Juan L. Iovanna,Palma Rocchi +8 more
TL;DR: Investigation of variations of TP53INP1 expression and their correlation to clinicopathological parameters in PC found variations correlate with poor prognosis in Prostate Cancer.
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Evidencing a pancreatic ductal adenocarcinoma subpopulation sensitive to the proteasome inhibitor Carfilzomib
Nicolas A. Fraunhoffer,Nicolas A. Fraunhoffer,Analía Meilerman Abuelafia,Martin Bigonnet,Odile Gayet,Julie Roques,Emmanuel Telle,Patricia Santofimia-Castaño,Maria Teresa Borrello,Eduardo Chuluyan,Nelson Dusetti,Juan L. Iovanna +11 more
TL;DR: The existence of a carfilzomib-sensitive PDAC subgroup with a specific transcriptomic phenotype that could explain the biological reason for this responsiveness is demonstrated.
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The E3 Ubiquitin Ligase Thyroid Hormone Receptor-interacting Protein 12 Targets Pancreas Transcription Factor 1a for Proteasomal Degradation
Naïma Hanoun,Samuel Fritsch,Odile Gayet,Véronique Gigoux,Pierre Cordelier,Nelson Dusetti,Jérôme Torrisani,Marlène Dufresne +7 more
TL;DR: It is reported that inhibition of proteasome leads to elevated levels of PTF1a and to the existence of polyubiquitinated forms of P TF1a, and the data suggest that an increase in TRIP12 expression can play a part in PTF 1a down-regulation and indicate that PTF2a/TRIP12 functional interaction may regulate pancreatic epithelial cell homeostasis.
Journal ArticleDOI
E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments.
Wenjun Lan,Benjamin Bian,Yi Xia,Samir Dou,Odile Gayet,Martin Bigonnet,Patricia Santofimia-Castaño,Mei Cong,Ling Peng,Nelson Dusetti,Juan L. Iovanna +10 more
TL;DR: An E2F target expression-based classification that could be predictive for patient outcome, but more important, for the sensitivity of tumors to the E 2F inhibitors as a treatment is described.