N
Nestor Gabriel Iglesias
Researcher at National University of Quilmes
Publications - 24
Citations - 1220
Nestor Gabriel Iglesias is an academic researcher from National University of Quilmes. The author has contributed to research in topics: Dengue virus & Flavivirus. The author has an hindex of 11, co-authored 21 publications receiving 1025 citations. Previous affiliations of Nestor Gabriel Iglesias include Fundación Instituto Leloir & National Scientific and Technical Research Council.
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The F1 Motif of Dengue Virus Polymerase NS5 Is Involved in Promoter-Dependent RNA Synthesis
TL;DR: Four NS5 mutants were selected to have polymerase activity in the recombinant protein but delayed or impaired virus replication when introduced into an infectious clone, suggesting a role of these amino acids in other functions of NS5.
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Dengue Virus Uses a Non-Canonical Function of the Host GBF1-Arf-COPI System for Capsid Protein Accumulation on Lipid Droplets.
Nestor Gabriel Iglesias,Juan Alberto Mondotte,Laura Andrea Byk,Federico Andres de Maio,Marcelo M. Samsa,Cecilia Alvarez,Andrea V. Gamarnik +6 more
TL;DR: The results support a model in which the virus uses a non‐canonical function of the COPI system for capsid accumulation on LDs, providing new ideas for antiviral strategies.
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Dynamic RNA structures in the dengue virus genome.
TL;DR: The current understanding of the function of different RNA elements that modulate dengue virus replication is discussed and new ideas of how dynamic RNA structures participate in the viral processes are provided.
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Population structure of Citrus tristeza virus from field Argentinean isolates
Nestor Gabriel Iglesias,Selma Gago-Zachert,Germán Robledo,Norma Costa,Maria Inés Plata,Osmar D. Vera,Oscar Grau,Liliana Semorile +7 more
TL;DR: The results showed a high intra-isolate sequence variability suggesting that re-infections could contribute to the observed variability and that the host can play an important role in the selection of the sequence variants present in these isolates.
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A Proline-Rich N-Terminal Region of the Dengue Virus NS3 Is Crucial for Infectious Particle Production.
Leopoldo German Gebhard,Nestor Gabriel Iglesias,Laura Andrea Byk,Claudia Veronica Filomatori,Federico Andres de Maio,Andrea V. Gamarnik +5 more
TL;DR: Evidence of a central role of NS3 in the coordination of both dengue virus RNA replication and particle formation is provided, and new ideas that include NS3 as a possible scaffold for the viral assembly process are proposed.