N
Nicholas A. Barnes
Researcher at University of Manchester
Publications - 44
Citations - 790
Nicholas A. Barnes is an academic researcher from University of Manchester. The author has contributed to research in topics: Phosphine & Transition metal. The author has an hindex of 13, co-authored 44 publications receiving 681 citations. Previous affiliations of Nicholas A. Barnes include National Institute for Health Research & St James's University Hospital.
Papers
More filters
Journal ArticleDOI
In Vitro Generation of Long-lived Human Plasma Cells
Mario Cocco,Sophie Stephenson,Matthew A. Care,Darren J. Newton,Nicholas A. Barnes,Adam Davison,Andy C. Rawstron,David R. Westhead,Gina M. Doody,Reuben Tooze,Reuben Tooze +10 more
TL;DR: A robust model for the generation of polyclonal long-lived human PCs from peripheral blood B cells is described, providing the first platform with which to sequentially explore and manipulate each stage of human PC differentiation.
Journal ArticleDOI
Blimp‐1 homolog Hobit identifies effector‐type lymphocytes in humans
Felipe A. Vieira Braga,Kirsten M. L. Hertoghs,Natasja A. M. Kragten,Gina M. Doody,Nicholas A. Barnes,Ester B. M. Remmerswaal,Cheng-Chih Hsiao,Perry D. Moerland,Diana Wouters,Ingrid A. M. Derks,Amber van Stijn,Marc Demkes,Jörg Hamann,Eric Eldering,Martijn A. Nolte,Reuben Tooze,Ineke J. M. ten Berge,Klaas P. J. M. van Gisbergen,René A. W. van Lier +18 more
TL;DR: This paper showed that the zinc finger protein homologue of Blimp-1 in T cells (Hobit) was uniformly expressed in effector-type CD8(+) T cells, but not in naive or in most memory CD8+ T cells.
Journal ArticleDOI
SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.
Matthew A. Care,Mario Cocco,Jon Laye,Nicholas A. Barnes,Yuanxue Huang,Ming Wang,S. Barrans,Ming Du,Andrew Jack,David R. Westhead,Gina M. Doody,Reuben Tooze,Reuben Tooze +12 more
TL;DR: In this paper, the authors assessed genome occupancy by IRF4 and endogenous cofactors in ABC-DLBCL cell lines, identifying distinct associations with SPIB occupancy, signatures of B-cell differentiation stage and potential pathogenetic mechanisms.
Journal ArticleDOI
BLIMP-1 and STAT3 Counterregulate MicroRNA-21 during Plasma Cell Differentiation
TL;DR: It is demonstrated that miR-21 is repressed during IL-21–driven plasma cell differentiation, and the molecular basis for this repression is explored, which indicates that STAT3 and BLIMP-1 constitute an incoherent feed-forward loop downstream of IL- 21 that can coordinate microRNA with mRNA expression during plasma cell differentiated.
Journal ArticleDOI
Network Analysis Identifies Proinflammatory Plasma Cell Polarization for Secretion of ISG15 in Human Autoimmunity.
Matthew A. Care,Sophie Stephenson,Nicholas A. Barnes,Im Fan,Alexandre Zougman,Yasser M. El-Sherbiny,Edward M Vital,David R. Westhead,Reuben Tooze,Gina M. Doody +9 more
TL;DR: It is shown that core PC programs are unaffected, whereas PCs respond to IFNs with distinctive transcriptional responses, leading to the identification of ISG15-secreting plasmablasts/PCs in patients with active systemic lupus erythematosus.