Nicholas C. O. Tomkinson

TL;DR: In this paper, the mouse and human pregnane X receptor (PXR) were shown to be activated by compounds that induce CYP3A expression in primary hepatocytes, and the authors reported the cloning and characterization of PXR from these two species, with the rabbit, rat and human receptors sharing only approximately 80% amino acid identity in their ligand-binding domains.

TL;DR: In this paper, the mouse and human pregnane X receptor (PXR) were shown to be activated by compounds that induce CYP3A expression in primary hepatocytes, and the authors reported the cloning and characterization of PXR from these two species, with the rabbit, rat and human receptors sharing only approximately 80% amino acid identity in their ligand-binding domains.

TL;DR: Interestingly, palmitoylated monomers of ANCL CSP α mutants were shown to be short-lived compared with wild-type CSPα, suggesting that the mutants either have a faster rate of depalmitoylation or that they are consumed in a time-dependent manner into high molecular weight aggregates.

TL;DR: I-BRD9 represents the first selective tool compound available to elucidate the cellular phenotype of BRD9 bromodomain inhibition, leading to greater than 700-fold selectivity over the BET family and 200-fold over the highly homologous bromidomain-containing protein 7 (BRD7).

TL;DR: A large-scale public-private partnership is proposed as a new approach that offers economies of scale, minimized redundancy and sharing of risk and cost.