A
Aled M. Edwards
Researcher at Structural Genomics Consortium
Publications - 433
Citations - 20332
Aled M. Edwards is an academic researcher from Structural Genomics Consortium. The author has contributed to research in topics: Crystal structure & Protein structure. The author has an hindex of 75, co-authored 427 publications receiving 18969 citations. Previous affiliations of Aled M. Edwards include McGill University & Montreal Neurological Institute and Hospital.
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Journal ArticleDOI
Protein production and purification.
Susanne Gräslund,Pär Nordlund,J Weigelt,B M Hallberg,James E. Bray,Opher Gileadi,Stefan Knapp,Udo Oppermann,Cheryl H. Arrowsmith,Raymond Hui,J Ming,Sirano Dhe-Paganon,Park H-W.,Alexei Savchenko,Adelinda Yee,Aled M. Edwards,Renaud Vincentelli,Christian Cambillau,R Kim,Kim S-H.,Zihe Rao,Yunyu Shi,Thomas C. Terwilliger,Kim C-Y.,Hung L-W.,Geoffrey S. Waldo,Yoav Peleg,Shira Albeck,Tamar Unger,Orly Dym,Jaime Prilusky,Joel L. Sussman,Raymond C. Stevens,Scott A. Lesley,Scott A. Lesley,Ian A. Wilson,Ian A. Wilson,Andrzej Joachimiak,Frank R. Collart,Irina Dementieva,Mark I. Donnelly,William H. Eschenfeldt,Youngchang Kim,Lucy Stols,Ruiying Wu,M. Zhou,Stephen K. Burley,J.S. Emtage,J.M. Sauder,D.A. Thompson,Kevin Bain,John G. Luz,Tarun Gheyi,F Zhang,Shane Atwell,Steven C. Almo,Jeffrey B. Bonanno,Andras Fiser,Soumya Swaminathan,F.W. Studier,Mark R. Chance,Andrej Sali,Thomas Acton,Rong Xiao,L Zhao,L C Ma,John F. Hunt,Liang Tong,Kellie Cunningham,Masayori Inouye,Stephen Anderson,Haleema Janjua,Ritu Shastry,C K Ho,D Wang,Hao Wang,M Jiang,Gaetano T. Montelione,David I. Stuart,Raymond J. Owens,S Daenke,Anja Schütz,Udo Heinemann,S Yokoyama,Konrad Büssow,Kristin C. Gunsalus,Kristin C. Gunsalus +86 more
TL;DR: This review presents methods that could be applied at the outset of any project, a prioritized list of alternate strategies and a list of pitfalls that trip many new investigators.
Journal ArticleDOI
The promise and peril of chemical probes.
Cheryl H. Arrowsmith,James E. Audia,Christopher M. Austin,Jonathan B. Baell,Jonathan Bennett,Julian Blagg,C. Bountra,Paul Brennan,Peter Brown,Mark E. Bunnage,Carolyn Buser-Doepner,Robert M. Campbell,Adrian Carter,Philip Cohen,Robert A. Copeland,Ben Cravatt,Jayme L. Dahlin,Dashyant Dhanak,Aled M. Edwards,Mathias Frederiksen,Stephen V. Frye,Nathanael S. Gray,Charles E. Grimshaw,David Hepworth,Trevor Howe,Kilian Huber,Jian Jin,Stefan Knapp,Joanne Kotz,Ryan G. Kruger,Derek B. Lowe,Mary M. Mader,Brian D. Marsden,Anke Mueller-Fahrnow,Susanne Müller,Ronan C. O'Hagan,John P. Overington,Dafydd R. Owen,Saul H Rosenberg,Bryan L. Roth,Ruth A. Ross,Matthieu Schapira,Stuart L. Schreiber,Brian K. Shoichet,Michael Sundström,Giulio Superti-Furga,Jack Taunton,Leticia Toledo-Sherman,Chris Walpole,Michael A. Walters,Timothy M. Willson,Paul Workman,Robert N. Young,William J. Zuercher +53 more
TL;DR: A community-driven wiki resource to improve quality and convey current best practice on chemical probes, and to help address shortcomings of poor quality or that are used incorrectly generate misleading results.
Journal ArticleDOI
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Masoud Vedadi,Frank H. Niesen,Abdellah Allali-Hassani,Oleg Fedorov,P.J. Finerty,Gregory A. Wasney,Ron Yeung,Cheryl H. Arrowsmith,Linda J. Ball,Helena Berglund,Raymond Hui,Brian D. Marsden,Pär Nordlund,Michael Sundström,J. Weigelt,Aled M. Edwards +15 more
TL;DR: Two screening platforms are implemented, based on either fluorimetry or static light scattering, to measure the increase in protein thermal stability upon binding of a ligand without the need to monitor enzyme activity, and a small molecule was identified that stabilized the proteins and promoted structure determination.
Journal ArticleDOI
Architecture of RNA polymerase II and implications for the transcription mechanism.
Patrick Cramer,David A. Bushnell,Jianhua Fu,Averell Gnatt,Barbara Maier-Davis,Nancy E. Thompson,Richard R. Burgess,Aled M. Edwards,Peter R. David,Roger D. Kornberg +9 more
TL;DR: A backbone model of a 10-subunit yeast RNA polymerase II has been derived from x-ray diffraction data extending to 3 angstroms resolution, and features of the model include a pair of jaws that appear to grip DNA downstream of the active center.
Journal ArticleDOI
Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA
TL;DR: The crystal structure at 2.4 Å resolution of the single-stranded- DNA-binding domain of human replication protein A (RPA) bound to DNA is reported, indicating that the mechanism of ssDNA-binding is conserved.