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Nicholas P. Cianciotto
Researcher at Northwestern University
Publications - 126
Citations - 6032
Nicholas P. Cianciotto is an academic researcher from Northwestern University. The author has contributed to research in topics: Legionella pneumophila & Mutant. The author has an hindex of 44, co-authored 123 publications receiving 5547 citations.
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Journal ArticleDOI
Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA.
Doreen E. Gillespie,Sean F. Brady,Alan D. Bettermann,Nicholas P. Cianciotto,Mark R. Liles,Michelle R. Rondon,Jon Clardy,Robert M. Goodman,Jo Handelsman +8 more
TL;DR: In this paper, a 24,546-member library in Escherichia coli with DNA extracted directly from soil had been constructed, and three clones, P57G4, P89C8, and P214D2, produced colonies with a dark brown melanin-like color.
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Type II secretion: a protein secretion system for all seasons
TL;DR: An analysis of numerous sequenced genomes now reveals that T2S genes are common, but by no means universal, in Gram-negative bacteria.
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Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung
TL;DR: The output of type II secretion is greater in magnitude than previously appreciated and includes previously undescribed proteins, and data indicate that an enzyme with chitinase activity can promote infection of a mammalian host.
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Legionella pneumophila Type II Protein Secretion Promotes Virulence in the A/J Mouse Model of Legionnaires' Disease Pneumonia
TL;DR: It is confirmed that PilD and type II secretion genes are required for L. pneumophila infection of both amoebae and human macrophages and the type II system controls the secretion of protease, RNase, lipase, phospholipase A, phosphate-sensitive and tartrate-sensitive acid phosphatase activities and influences the appearance of colonies.
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Legionella pneumophila feoAB Promotes Ferrous Iron Uptake and Intracellular Infection
TL;DR: Results indicate that L. pneumophila FeoB is a ferrous iron transporter that is important for extracellular and intracellular growth, especially in iron-limited environments, and represents the first evidence for the importance of ferrousIron transport for intrACEllular replication by a human pathogen.