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Nick G. Coldham
Researcher at Veterinary Laboratories Agency
Publications - 69
Citations - 4576
Nick G. Coldham is an academic researcher from Veterinary Laboratories Agency. The author has contributed to research in topics: Sulforaphane & Isothiocyanate. The author has an hindex of 37, co-authored 69 publications receiving 4287 citations. Previous affiliations of Nick G. Coldham include Animal and Plant Health Agency & Imperial College London.
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Journal ArticleDOI
Concentrations of parabens in human breast tumours
TL;DR: Initial studies reported here show that parabens can be extracted from human breast tissue and detected by thin‐layer chromatography and this should open the way technically for more detailed information to be obtained on body burdens of paraben and in particular whether body burdens are different in cancer from those in normal tissues.
Journal ArticleDOI
Evaluation of a recombinant yeast cell estrogen screening assay.
Nick G. Coldham,M. Dave,Susila Sivapathasundaram,Donald P. McDonnell,Caroline Connor,Maurice J. Sauer +5 more
TL;DR: The recombinant yeast cell bioassay (RCBA) was approximately two and five orders of magnitude more sensitive to E2 than MCF-7 cells and the uterotrophic assay, respectively, and the estrogenic potency of 53 chemicals was measured using the RCBA.
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in situ oestrone synthesis in normal breast and breast tumour tissues: Effect of treatment with 4‐hydroxyandrostenedione
TL;DR: It is concluded that in some, but not all, breast tumours in situ formation of oestrone can make an important contribution to the oestrogen content of breast tumour content.
Journal ArticleDOI
Pharmacokinetics of [14C]genistein in the rat: gender-related differences, potential mechanisms of biological action, and implications for human health.
Nick G. Coldham,Maurice J. Sauer +1 more
TL;DR: Significantly increased retention of [(14)C]genistein or metabolites was associated with reproductive organs, such as vagina, uterus, ovary, and prostate, likely to contain relatively high concentrations of estrogen receptors or binding proteins compared with other peripheral tissues.
Journal ArticleDOI
Oestrogenic activity of benzylparaben.
Philippa D. Darbre,J. R. Byford,L. E. Shaw,S. Hall,Nick G. Coldham,G. S. Pope,Maurice J. Sauer +6 more
TL;DR: It is demonstrated that the oestrogenicity of methylparaben can be increased by the addition of an aryl group as well as by lengthening or branching the alkyl grouping.