Nicola Wiechens

TL;DR: A chromatin-remodeling enzyme, ALC1 (Amplified in Liver Cancer 1, also known as CHD1L), is identified that interacts with poly(ADP-ribose) and catalyzes PARP1-stimulated nucleosome sliding and provides new insights into the mechanisms by which poly(adenosine 5′-diphosphate (ADP)–riboses) regulates DNA repair.

TL;DR: Proteolysis targeting chimera (PROTAC) degraders of the BAF ATPase subunits SMARCA2 andSMARCA4 are developed using a bromodomain ligand and recruitment of the E3 ubiquitin ligase VHL to degrade high profile drug targets and induce cancer cell death.

TL;DR: It is demonstrated that APLF exhibits histone chaperone activities in a manner that is dependent on its acidic domain and that the NAP1L motif is critical for the repair capacity of APLf in vivo.

TL;DR: Variation of histone sequence or subtype provides a means by which eukaryotes may regulate access to chromatin through alterations to nucleosome mobility.

TL;DR: It is found that the ATP-dependent chromatin remodelling enzyme SNF2H plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor C TCF sites and acts to promote CTCF binding.