M
Mark Skehel
Researcher at London Research Institute
Publications - 12
Citations - 2176
Mark Skehel is an academic researcher from London Research Institute. The author has contributed to research in topics: Cohesin & Separase. The author has an hindex of 12, co-authored 12 publications receiving 1957 citations. Previous affiliations of Mark Skehel include University of Cambridge & Francis Crick Institute.
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Journal ArticleDOI
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Dragana Ahel,Zuzana Hořejší,Nicola Wiechens,Sophie E. Polo,Elisa Garcia-Wilson,Ivan Ahel,Ivan Ahel,Helen R. Flynn,Mark Skehel,Stephen C. West,Stephen P. Jackson,Tom Owen-Hughes,Simon J. Boulton +12 more
TL;DR: A chromatin-remodeling enzyme, ALC1 (Amplified in Liver Cancer 1, also known as CHD1L), is identified that interacts with poly(ADP-ribose) and catalyzes PARP1-stimulated nucleosome sliding and provides new insights into the mechanisms by which poly(adenosine 5′-diphosphate (ADP)–riboses) regulates DNA repair.
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Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion
Tom Rolef Ben-Shahar,Sebastian Heeger,Chris Lehane,Philip East,Helen R. Flynn,Mark Skehel,Frank Uhlmann +6 more
TL;DR: The results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent.
Journal ArticleDOI
F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells
Susan Ahrens,Santiago Zelenay,David Sancho,Pavel Hanč,Svend Kjaer,Christoph Feest,Georgina C. Fletcher,Charlotte H. Durkin,Antonio Postigo,Mark Skehel,Facundo D. Batista,Barry J. Thompson,Michael Way,Caetano Reis e Sousa,Oliver Schulz +14 more
TL;DR: The identification of F-actin as a DNGR-1 ligand suggests that cytoskeletal exposure is a universal sign of cell damage that can be targeted by the innate immune system to initiate immunity.
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Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Keiko Yata,Janette Lloyd,Sarah L. Maslen,Jean-Yves Bleuyard,Mark Skehel,Stephen J. Smerdon,Fumiko Esashi +6 more
TL;DR: It is reported that Polo-like kinase 1 (Plk1), which is vital for cell proliferation and is frequently upregulated in cancer cells, phosphorylates the essential Rad51 recombinase at serine 14 (S14) during the cell cycle and in response to DNA damage.
Journal ArticleDOI
Hos1 deacetylates Smc3 to close the cohesin acetylation cycle.
Vanessa Borges,Chris Lehane,Lidia Lopez-Serra,Helen R. Flynn,Mark Skehel,Tom Rolef Ben-Shahar,Frank Uhlmann +6 more
TL;DR: It is shown that the class I histone deacetylase family member Hos1 is responsible for Smc3 deacetyation, and unexpected insight is provided into the importance of de novo Smc 3 acetylation for cohesion establishment.