N
Nicolas Coudray
Researcher at New York University
Publications - 63
Citations - 2562
Nicolas Coudray is an academic researcher from New York University. The author has contributed to research in topics: Bacterial outer membrane & Cell envelope. The author has an hindex of 13, co-authored 54 publications receiving 1490 citations. Previous affiliations of Nicolas Coudray include University of Upper Alsace & University of York.
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Journal ArticleDOI
Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.
Nicolas Coudray,Paolo S. Ocampo,Theodore Sakellaropoulos,Navneet Narula,Matija Snuderl,David Fenyö,Andre L. Moreira,Narges Razavian,Aristotelis Tsirigos +8 more
TL;DR: A deep convolutional neural network model is trained on whole-slide images obtained from The Cancer Genome Atlas to accurately and automatically classify them into LUAD, LUSC or normal lung tissue and predicts the ten most commonly mutated genes in LUAD.
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Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy
Nicolas Coudray,Salvatore Valvo,Minghui Hu,Ralph Lasala,Changki Kim,Martin Vink,Ming Zhou,Davide Provasi,Marta Filizola,Juoehi Tao,Jia Fang,Pawel A. Penczek,Iban Ubarretxena-Belandia,David L. Stokes +13 more
TL;DR: Cryoelectron microscopy and molecular dynamics simulation of YiiP in a lipid environment were used to address the feasibility of a conformational change that involves pivoting of a transmembrane, four-helix bundle relative to the M3-M6 helix pair.
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Using Machine Learning Algorithms to Predict Immunotherapy Response in Patients with Advanced Melanoma
Paul Johannet,Nicolas Coudray,Douglas Donnelly,George Jour,Irineu Illa-Bochaca,Yuhe Xia,Douglas B. Johnson,Lee Wheless,James R. Patrinely,Sofia Nomikou,David L. Rimm,Anna C. Pavlick,Jeffrey S. Weber,Judy Zhong,Aristotelis Tsirigos,Iman Osman +15 more
TL;DR: A pipeline that integrates deep learning on histology specimens with clinical data to predict ICI response in advanced melanoma is developed that has potential for integration into clinical practice.
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Structural basis for the alternating access mechanism of the cation diffusion facilitator YiiP
TL;DR: The physical changes that a bacterial transporter uses to carry Zn2+ across cell membranes are deduced and dimer stability was not compromised by mutagenesis of elements in the cytoplasmic domain, suggesting that the extensive interface between membrane domains is a strong determinant of dimerization.
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Robust threshold estimation for images with unimodal histograms
TL;DR: The proposed technique is based on a piecewise linear regression to fit the whole descending slope of the histogram, rather than the search of some specific points, and gives a reliable estimation of the threshold.