N
Nicolas Kolocouris
Researcher at National and Kapodistrian University of Athens
Publications - 48
Citations - 1139
Nicolas Kolocouris is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Rimantadine & Influenza A virus. The author has an hindex of 17, co-authored 48 publications receiving 1075 citations. Previous affiliations of Nicolas Kolocouris include University of London.
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Journal ArticleDOI
Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.
Nicolas Kolocouris,Antonios Kolocouris,G. B. Foscolos,G. Fytas,Johan Neyts,E. Padalko,Jan Balzarini,Robert Snoeck,Graciela Andrei,E. De Clercq +9 more
TL;DR: None of the new aminoadamantane derivatives was active against influenza B virus or any of the other viruses tested, which points to their specificity as anti-influenza A virus agents.
Journal ArticleDOI
Spiro[pyrrolidine-2,2'-adamantanes]: synthesis, anti-influenza virus activity and conformational properties.
Ioannis Stylianakis,Antonios Kolocouris,Nicolas Kolocouris,G. Fytas,George B. Foscolos,Elizaveta Padalko,Johan Neyts,Erik De Clercq +7 more
TL;DR: This new series of anti-influenza virus A compounds is characterized by a lipophilic part, that is the pyrrolidine ring, in addition to adamantane, that can interact with influenza A M2 protein, an ultimate future goal would be the in vitro mapping of M2 Lipophilic pocket.
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Heterocyclic rimantadine analogues with antiviral activity
George Stamatiou,George B. Foscolos,G. Fytas,Antonios Kolocouris,Nicolas Kolocouris,Christophe Pannecouque,Myriam Witvrouw,Elizaveta Padalko,Johan Neyts,Erik De Clercq +9 more
TL;DR: It appears that changing the five-, to four- to a three-membered ring results in a drop of activity against influenza A virus.
Journal ArticleDOI
Design and synthesis of bioactive adamantane spiro heterocycles.
Nicolas Kolocouris,Grigoris Zoidis,George B. Foscolos,G. Fytas,S. Radhika Prathalingham,John M. Kelly,Lieve Naesens,Erik De Clercq +7 more
TL;DR: Piperidine 25 showed significant anti-influenza A virus activity and proved to be the most active of the compounds tested against bloodstream forms of the African trypanosome, Trypanosoma brucei, being 1.5 times more potent than rimantadine and at least 25 times more active than amantadines.
Journal ArticleDOI
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
Antonios Kolocouris,Kostas Dimas,Christophe Pannecouque,Myriam Witvrouw,George B. Foscolos,George Stamatiou,G. Fytas,Grigoris Zoidis,Nicolas Kolocouris,Graciela Andrei,Robert Snoeck,Erik De Clercq +11 more
TL;DR: Using a combination of molecular mechanics calculations and NOE spectroscopy it was shown that the parent compounds and have opposite configuration around C=N bond, whether this difference in structure can be correlated with the biological activity will be investigated in future studies.