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Antonios Kolocouris
Researcher at National and Kapodistrian University of Athens
Publications - 105
Citations - 2566
Antonios Kolocouris is an academic researcher from National and Kapodistrian University of Athens. The author has contributed to research in topics: Chemistry & Rimantadine. The author has an hindex of 23, co-authored 90 publications receiving 1813 citations. Previous affiliations of Antonios Kolocouris include Rega Institute for Medical Research.
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Journal ArticleDOI
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers.
Venkata S. Mandala,Matthew J. McKay,Alexander A. Shcherbakov,Aurelio J. Dregni,Antonios Kolocouris,Mei Hong +5 more
TL;DR: The structure and the drug-binding site of E’s transmembrane domain (ETM), determined using solid-state NMR spectroscopy, sets the stage for designing E inhibitors as antiviral drugs.
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Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L
Michael Dominic Sacco,Chunlong Ma,Panagiotis Lagarias,Ang Gao,Julia Alma Townsend,Xiangzhi Meng,Peter H. Dube,Xiujun Zhang,Yanmei Hu,Naoya Kitamura,Brett L. Hurst,Bart Tarbet,Michael T. Marty,Antonios Kolocouris,Yan Xiang,Yu Chen,Jun Wang +16 more
TL;DR: The structure of Mpro with calpain inhibitor II confirmed that the S1 pocket can accommodate a hydrophobic methionine side chain, challenging the idea that a Hydrophilic residue is necessary at this position.
Journal ArticleDOI
Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors
Chunlong Ma,Yanmei Hu,Julia Alma Townsend,Panagiotis Lagarias,Michael T. Marty,Antonios Kolocouris,Jun Wang +6 more
TL;DR: Overall, compelling evidence is provided suggesting that these six compounds are nonspecific SARS-CoV-2 Mpro inhibitors and urge the scientific community to be stringent with hit validation.
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Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2.
Nicolas Kolocouris,Antonios Kolocouris,G. B. Foscolos,G. Fytas,Johan Neyts,E. Padalko,Jan Balzarini,Robert Snoeck,Graciela Andrei,E. De Clercq +9 more
TL;DR: None of the new aminoadamantane derivatives was active against influenza B virus or any of the other viruses tested, which points to their specificity as anti-influenza A virus agents.
Journal ArticleDOI
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory
Zoe Cournia,Toby W. Allen,Toby W. Allen,Ioan Andricioaei,Bruno Antonny,Daniel Baum,Grace Brannigan,Nicolae-Viorel Buchete,Jason Deckman,Lucie Delemotte,Coral del Val,Ran Friedman,Paraskevi Gkeka,Hans-Christian Hege,Jérôme Hénin,Marina A. Kasimova,Marina A. Kasimova,Antonios Kolocouris,Michael L. Klein,Syma Khalid,M. Joanne Lemieux,Norbert Lindow,Mahua Roy,Jana Selent,Mounir Tarek,Mounir Tarek,Florentina Tofoleanu,Stefano Vanni,Sinisa Urban,David J. Wales,Jeremy C. Smith,Ana-Nicoleta Bondar +31 more
TL;DR: Current studies in computational and experimental membrane protein biophysics are presented, and how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins are shown.