N
Nicolas Mendez
Researcher at University of Texas at Austin
Publications - 10
Citations - 966
Nicolas Mendez is an academic researcher from University of Texas at Austin. The author has contributed to research in topics: Stromal cell & Tumor microenvironment. The author has an hindex of 9, co-authored 10 publications receiving 542 citations. Previous affiliations of Nicolas Mendez include Spanish National Research Council & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
Mohammad Shahnawaz,Abhisek Mukherjee,Sandra Pritzkow,Nicolas Mendez,Prakruti Rabadia,Xiangan Liu,Bo Hu,Ann M. Schmeichel,Wolfgang Singer,Gang Wu,Ah Lim Tsai,Hamid Shirani,K. Peter R. Nilsson,Phillip A. Low,Claudio Soto +14 more
TL;DR: The α-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson’s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%.
Journal ArticleDOI
Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid
Mohammad Shahnawaz,Takahiko Tokuda,Masaaki Waragai,Nicolas Mendez,Ryotaro Ishii,Claudia Trenkwalder,Brit Mollenhauer,Claudio Soto +7 more
TL;DR: The findings suggest that detection of &agr;Syn oligomers by &agR;Syn-PMCA in the CSF of patients affected by PD may offer a good opportunity for a sensitive and specific biochemical diagnosis of the disease.
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Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism.
Abhisek Mukherjee,Diego Morales-Scheihing,Diego Morales-Scheihing,Natalia Salvadores,Natalia Salvadores,Ines Moreno-Gonzalez,Cesar Gonzalez,Kathleen Taylor-Presse,Nicolas Mendez,Mohammad Shahnawaz,A. Osama Gaber,Omaima M. Sabek,Daniel W. Fraga,Claudio Soto,Claudio Soto +14 more
TL;DR: It is shown that pancreatic IAPP aggregates can promote the misfolding and aggregation of endogenous IAPP in islet cultures obtained from transgenic mouse or healthy human pancreas, and this suggests that some of the pathologic and clinical alterations of T2D might be transmissible through a similar mechanism by which prions propagate in prion diseases.
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Synthesis of nanostructured porous silica coatings on titanium and their cell adhesive and osteogenic differentiation properties
Débora Inzunza,Cristian Covarrubias,Alfredo Von Marttens,Y Leighton,JC Carvajal,Francisco Valenzuela,Mario Díaz-Dosque,Nicolas Mendez,Constanza Martínez,Ana María Pino,Juan Pablo Rodríguez,Mónica Cáceres,Patricio C. Smith +12 more
TL;DR: The bioactive surface properties exhibited by the nanostructured porous silica coatings make these materials a promising alternative to improve the osseointegration properties of titanium dental implants and could have future impact on the nanoscale design of implant surfaces.
Journal ArticleDOI
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential
Nelson Ferreira,Hjalte Gram,Zachary A. Sorrentino,Emil Gregersen,Sissel Ida Schmidt,Lasse Reimer,Cristine Betzer,Clara Perez-Gozalbo,Marjo Beltoja,Madhu Nagaraj,Jie Wang,Jie Wang,Jan Stanislaw Nowak,Mingdong Dong,Katarina Willén,Ersoy Cholak,Kaare Bjerregaard-Andersen,Nicolas Mendez,Prakruti Rabadia,Mohammad Shahnawaz,Claudio Soto,Daniel E. Otzen,Ümit Akbey,Morten Meyer,Benoit I. Giasson,Marina Romero-Ramos,Poul Henning Jensen +26 more
TL;DR: In this article, the α-Syn/p25α strain induced by the multiple system atrophy-associated oligodendroglial protein p25α was found to have a more pronounced motoric phenotype and exhibited a "tropism" for nigro-striatal neurons compared to α-syn PFF.