Nicolás Olea

TL;DR: Positive and statistically significant correlations between adipose tissue and serum concentrations only in p,p'-DDE and HCB are found, which underlines the need for human biomonitoring to assess exposure to environmental pollutants in South America.

TL;DR: A method to assess the total estrogenic xenobiotic burden in human adipose tissue and the high percentage of positive samples suggests that the method is sensitive enough to be used as a biomarker of human exposure to estrogenic Xenobiotics and can be applied in epidemiological studies.

TL;DR: Adipose tissue NP and OP levels are similar to the few data previously published in other countries, but further research is needed to determine trends in human exposure to these compounds and to investigate their consequences.

TL;DR: The protocol for extensive fractionation of a higher number of tissue samples is improved in order to investigate bioaccumulated xenoestrogens that are candidates for estrogenicity and to assess their combined estrogenic effect.

TL;DR: Results indicated that although medroxyprogesterone induced maximal proliferation at 3 X 10(-9) M, the other "anti-androgens" (with the exception of flutamide that was ineffective) were effective at 3X 10(-8) M and higher concentrations; the amplitude of the proliferative response by these compounds was comparable to that elicited by estradiol-17 beta.