N
Nicole Gallo-Payet
Researcher at Université de Sherbrooke
Publications - 180
Citations - 6395
Nicole Gallo-Payet is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Angiotensin II & Receptor. The author has an hindex of 46, co-authored 180 publications receiving 6111 citations. Previous affiliations of Nicole Gallo-Payet include King's College London & Faculté de médecine – Université de Sherbrooke.
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Journal ArticleDOI
Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.
Yiqian Wan,Charlotta Wallinder,Bianca Plouffe,Hélène Beaudry,A. K. Mahalingam,Xiongyu Wu,Berndt Johansson,Mathias Holm,Milad Botoros,Anders Karlén,Anders Pettersson,Fred Nyberg,Lars Fändriks,Nicole Gallo-Payet,Anders Hallberg,Mathias Alterman +15 more
TL;DR: The first druglike selective angiotensin II AT(2) receptor agonist (21) with a K(i) value of 0.4 nM with a bioavailability of 20-30% after oral administration and a half-life estimated to 4 h in rat, induces outgrowth of neurite cells, stimulates p42/p44(mapk), and enhances in vivo duodenal alkaline secretion in Sprague-Dawley rats.
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Angiotensin II Induction of Neurite Outgrowth by AT2 Receptors in NG108-15 Cells: EFFECT COUNTERACTED BY THE AT1 RECEPTORS
TL;DR: The results demonstrate that the AT1 receptor inhibit the process of differentiation induced by dibutyryl cAMP, whereas the AT2 receptors potentiate this effect, illustrating negative cross-talk interaction between the two types of Ang II receptors.
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The Melanocortin System in Fugu: Determination of POMC/AGRP/MCR Gene Repertoire and Synteny, As Well As Pharmacology and Anatomical Distribution of the MCRs
Janis Klovins,Tatjana Haitina,Davids Fridmanis,Zuzana Kilianova,Ivo Kapa,Robert Fredriksson,Nicole Gallo-Payet,Helgi B. Schiöth +7 more
TL;DR: The study shows that some parts of the MC system are highly conserved through vertebrate evolution, such as regions in POMC coding for ACTH, alpha- MSH, and beta-MSH, the C-terminal region of AGRP, key binding units within the MC1R, MC2R,MC4R, and MC5R, synteny blocks around the MCRs, and pharmacological properties of theMC2R.
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The angiotensin AT2 receptor modulates T-type calcium current in non-differentiated NG108-15 cells.
TL;DR: Angiotensin II and the AT2 receptor‐selective ligand, CGP 42112, modulate the T‐type calcium current in non‐differentiated NG108‐15 cells, which express only AT2 receptors, and it is suggested that the AT1 receptor mediates certain neurophysiological actions of this hormone.
Journal ArticleDOI
A G protein is involved in the angiotensin AT2 receptor inhibition of the T-type calcium current in non-differentiated NG108-15 cells.
Bruno Buisson,Liette Laflamme,Serge P. Bottari,Marc de Gasparo,Nicole Gallo-Payet,Marcel D. Payet +5 more
TL;DR: The data suggest that phosphotyrosine phosphatase activation is proximal to receptor occupation, since sodium orthovanadate inhibits both GTPase activity and T-type current blockage induced by Ang II or CGP 42112, while GTPS inhibition of the T- type calcium current is not impaired.