Nicole Nuesgen

TL;DR: DNA methylation changes were widespread on all autosomal chromosomes in 45,X and in 47,XXY individuals, with Turner individuals presenting five times more affected loci, which suggests a certain stochastic/random contribution to the methylationChanges at each locus.

TL;DR: Long interspersed nuclear elements (LINE‐1) sequences constitute a substantial portion of the human genome, and their methylation often correlating with global genomic methylation, but most studies are based on only a few specific LINE‐1 CpG sites.

TL;DR: It is shown that genomic inversions in the F8 (Xq28) region are associated with detectable changes in methylation levels and can be used as an epigenetic diagnostic marker.

TL;DR: The transcriptional repressor ZBTB16 was identified as an interacting protein of NLRP7 and verified this interaction in mammalian cells by immunoprecipitation and confocal microscopy and a clear effect of harvesting ZBT B16 to the cytoplasm when theNLRP7 protein is overexpressed may be linked to the pathology of the molar pregnancy disease.

TL;DR: A high variability of S-COMT promoter methylation was observed, which did not correlate with individual differences in the pre- or postnatal growth pattern, but within the twin pairs however a distinct similarity was noted that could be linked to underlying COMT genotypes.