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Niels C. Danbolt
Researcher at University of Oslo
Publications - 112
Citations - 16178
Niels C. Danbolt is an academic researcher from University of Oslo. The author has contributed to research in topics: Glutamate receptor & Glutamate aspartate transporter. The author has an hindex of 60, co-authored 111 publications receiving 15044 citations. Previous affiliations of Niels C. Danbolt include Zhengzhou University & Hebrew University of Jerusalem.
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Journal ArticleDOI
Cloning and expression of a rat brain L-glutamate transporter.
Gilia Pines,Niels C. Danbolt,Magnar Bjørås,Magnar Bjørås,Yumin Zhang,Annie Bendahan,Lars Eide,Lars Eide,Hermann Koepsell,Jon Storm-Mathisen,Erling Seeberg,Erling Seeberg,Baruch I. Kanner +12 more
TL;DR: An antibody against a glial L-glutamate transporter from rat brain is used to isolate a complemen-tary DNA clone encoding this transporter, which predicts a protein of 573 amino acids with 8–9 putative transmembrane α-helices that seems to be a member of a new family of transport molecules.
Journal ArticleDOI
Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations
TL;DR: Preembedding light and electron microscopical immunocytochemistry shows that both GLT-1 and GLAST are restricted to astrocytes, which appear to express both proteins concomitantly, but in different proportions in different parts of the brain.
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Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry
Farrukh A. Chaudhry,Knut P. Lehre,Menno van Lookeren Campagne,Ole Petter Ottersen,Niels C. Danbolt,Jon Storm-Mathisen +5 more
TL;DR: The glutamate transporters GLT-1 and GLAST were studied by immunogold labeling on ultrathin sections of rat brain tissue embedded in acrylic resins at low temperature after freeze substitution to suggest the localizations of glutamate transportters are carefully regulated.
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The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction
TL;DR: The data support the idea that in pathophysiological conditions, the perivascular astrocytic covering may control the exchange of water and solutes between blood and brain and that free diffusion is limited to narrow clefts between overlapping endfeet.
Journal ArticleDOI
The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain.
Knut P. Lehre,Niels C. Danbolt +1 more
TL;DR: The role of glial glutamate transporters in limiting synaptic spillover is likely to vary between the two regions because of differences in the distribution of astroglia, and this work shows that GLAST and GLT molecules in the membranes around 2300 and 8500 μm−2 in the former and 4700 and 740 μm·cm3 in the latter region.