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Nigel J. Gooderham
Researcher at Imperial College London
Publications - 175
Citations - 5375
Nigel J. Gooderham is an academic researcher from Imperial College London. The author has contributed to research in topics: 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine & Carcinogen. The author has an hindex of 40, co-authored 169 publications receiving 4800 citations. Previous affiliations of Nigel J. Gooderham include New York State Department of Health & University of London.
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Journal Article
CYP1A2-catalyzed Conversion of Dietary Heterocyclic Amines to Their Proximate Carcinogens Is Their Major Route of Metabolism in Humans
Alan R. Boobis,Anthony M. Lynch,Stephen Murray,R. de la Torre,A. Solans,Magí Farré,Jordi Segura,Nigel J. Gooderham,Donald S. Davies +8 more
TL;DR: The contribution of CYP1A2 to the metabolism of the dietary heterocyclic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and MeIQx) in vivo in humans, has been determined with furafylline, a highly selective inhibitor of this enzyme.
Journal ArticleDOI
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.
Christoph Sachse,Upinder Bhambra,Gillian Smith,Tracy Lightfoot,Jennifer H. Barrett,Jenna Scollay,R. Colin Garner,Alan R. Boobis,C. Roland Wolf,Nigel J. Gooderham +9 more
TL;DR: In vivo CYP1A2 activity is lower in colorectal cancer patients than in controls, and the genotype had no effect on phenotype (based on the caffeine metabolite ratio), but this remains to be confirmed in a larger study.
Journal Article
GRAS flavoring substances 25
Robert L. Smith,William J. Waddell,Samuel M. Cohen,Shoji Fukushima,Nigel J. Gooderham,Stephen S. Hecht,Lawrence J. Marnett,Philip S. Portoghese,Ivonne M.C.M. Rietjens,T. B. Adams,C. Lucas Gavin,M. M. McGowen,Sean V. Taylor +12 more
TL;DR: The 25th publication by the Expert Panel of the Flavor and Extract Manufacturers Association provides an update on recent progress in the consideration of flavoring ingredients generally recognized as safe under the Food Additives Amendment.
Journal ArticleDOI
Metabolic surgery and cancer: protective effects of bariatric procedures.
Hutan Ashrafian,Kamran Ahmed,Simon P. Rowland,Vanash M. Patel,Nigel J. Gooderham,Elaine Holmes,Ara Darzi,Thanos Athanasiou +7 more
TL;DR: Elucidating the precise metabolic mechanisms of cancer prevention by metabolic surgery can increase the understanding of how obesity, diabetes, and metabolic syndrome are associated with cancer.
Journal Article
Intra- and Interindividual Variability in Systemic Exposure in Humans to 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, Carcinogens Present in Cooked Beef
Anthony M. Lynch,Mark G. Knize,Alan R. Boobis,Nigel J. Gooderham,Donald S. Davies,Stephen D. Murray +5 more
TL;DR: Assays based on capillary column gas chromatography-negative ion mass spectrometry capable of the simultaneous measurement of MeIQx, DiMe IQx, and PhIP in cooked meat and in human urine using stable isotope labeled analogues are developed.