N
Nikos Kourtis
Researcher at New York University
Publications - 19
Citations - 1245
Nikos Kourtis is an academic researcher from New York University. The author has contributed to research in topics: Ubiquitin ligase & Heat shock. The author has an hindex of 13, co-authored 18 publications receiving 1029 citations. Previous affiliations of Nikos Kourtis include Foundation for Research & Technology – Hellas & Howard Hughes Medical Institute.
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Cellular stress response pathways and ageing: intricate molecular relationships
TL;DR: The molecular mechanisms that link ageing to main stress response pathways are surveyed, and how each pathway contributes to modulate the ageing process is discussed.
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Autophagy and cell death in model organisms.
TL;DR: Current research in simple organisms is surveyed, linking autophagy to cell death and the complex interplay between Autophagy, cell survival and cell death is discussed.
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Small heat-shock proteins protect from heat-stroke-associated neurodegeneration
TL;DR: It is shown that heat stroke triggers pervasive necrotic cell death and neurodegeneration in Caenorhabditis elegans, and preconditioning of animals at a mildly elevated temperature strongly protects from heat-induced necrosis.
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20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans
Niki Chondrogianni,Konstantina Georgila,Nikos Kourtis,Nektarios Tavernarakis,Efstathios S. Gonos +4 more
TL;DR: This is the first report demonstrating that 20S core proteasome up‐regulation in terms of both content and activity is feasible in a multicellular eukaryotic organism and that in turn this modulation promotes extension of organismal health span and life span.
Journal ArticleDOI
FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification
Nikos Kourtis,Nikos Kourtis,Rana S. Moubarak,Beatriz Aranda-Orgilles,Beatriz Aranda-Orgilles,Kevin P. Lui,Iraz T. Aydin,Thomas Trimarchi,Thomas Trimarchi,Farbod Darvishian,Christine Salvaggio,Judy Zhong,Kamala Bhatt,Kamala Bhatt,Emily I. Chen,Julide T. Celebi,Charalampos Lazaris,Charalampos Lazaris,Aristotelis Tsirigos,Aristotelis Tsirigos,Iman Osman,Eva Hernando,Iannis Aifantis,Iannis Aifantis +23 more
TL;DR: It is shown that the ubiquitin ligase FBXW7α interacts with HSF1 through a conserved motif phosphorylated by GSK3β and ERK1, which identifies a post-translational mechanism of regulation of the HSF 1 transcriptional program both in the presence of exogenous stress and in cancer.