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Iannis Aifantis
Researcher at New York University
Publications - 214
Citations - 19632
Iannis Aifantis is an academic researcher from New York University. The author has contributed to research in topics: Cellular differentiation & T cell. The author has an hindex of 71, co-authored 188 publications receiving 16132 citations. Previous affiliations of Iannis Aifantis include University of Chicago & Howard Hughes Medical Institute.
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Journal ArticleDOI
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Kelly Moran-Crusio,Linsey Reavie,Alan Shih,Omar Abdel-Wahab,Delphine Ndiaye-Lobry,Camille Lobry,Maria E. Figueroa,Aparna Vasanthakumar,Jay P. Patel,Xinyang Zhao,Fabiana Perna,Suveg Pandey,Jozef Madzo,Chun-Xiao Song,Qing Dai,Chuan He,Sherif Ibrahim,Miloslav Beran,Jiri Zavadil,Stephen D. Nimer,Stephen D. Nimer,Ari Melnick,Lucy A. Godley,Iannis Aifantis,Ross L. Levine +24 more
TL;DR: An animal model of conditional Tet2 loss in the hematopoietic compartment that leads to increased stem cell self-renewal in vivo as assessed by competitive transplant assays is reported.
Journal ArticleDOI
The bone marrow microenvironment at single-cell resolution.
Anastasia N. Tikhonova,Igor Dolgalev,Hai Hu,Kishor K. Sivaraj,Edlira Hoxha,Álvaro Cuesta-Domínguez,Sandra Pinho,Ilseyar Akhmetzyanova,Jie Gao,Matthew T. Witkowski,Maria Guillamot,Michael C. Gutkin,Yutong Zhang,Christian Marier,Catherine Diefenbach,Stavroula Kousteni,Adriana Heguy,Hua Zhong,David R. Fooksman,Jason M. Butler,Aris N. Economides,Paul S. Frenette,Ralf H. Adams,Rahul Satija,Aristotelis Tsirigos,Iannis Aifantis +25 more
TL;DR: This analysis revealed previously unappreciated levels of cellular heterogeneity within the bone marrow niche and resolved cellular sources of pro-haematopoietic growth factors, chemokines and membrane-bound ligands as well as substantial transcriptional remodelling under stress conditions.
Journal ArticleDOI
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Omar Abdel-Wahab,Mazhar Adli,Lindsay M. LaFave,Jie Gao,Todd Hricik,Alan H. Shih,Suveg Pandey,Jay P. Patel,Young Rock Chung,Richard Koche,Fabiana Perna,Xinyang Zhao,Jordan E. Taylor,Christopher Y. Park,Martin Carroll,Ari Melnick,Stephen D. Nimer,Jacob D. Jaffe,Iannis Aifantis,Bradley E. Bernstein,Ross L. Levine,Ross L. Levine +21 more
TL;DR: It is identified that ASXL1 mutations result in loss of polycomb repressive complex 2 (PRC2)-mediated histone H3 lysine 27 (H3K27) tri-methylation, and that loss of AS XL1 in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.
Journal ArticleDOI
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Luisa Cimmino,Igor Dolgalev,Yubao Wang,Akihide Yoshimi,Gaëlle H. Martin,Jingjing Wang,Victor Ng,Bo Xia,Matthew T. Witkowski,Marisa Mitchell-Flack,Isabella Grillo,Sofia Bakogianni,Delphine Ndiaye-Lobry,Miguel Torres Martin,Maria Guillamot,Robert S. Banh,Mingjiang Xu,Maria E. Figueroa,Ross A. Dickins,Omar Abdel-Wahab,Christopher Y. Park,Aristotelis Tsirigos,Benjamin G. Neel,Iannis Aifantis +23 more
TL;DR: TET-mediated DNA oxidation induced by vitamin C treatment in leukemia cells enhances their sensitivity to PARP inhibition and could provide a safe and effective combination strategy to selectively target TET deficiency in cancer.
Journal ArticleDOI
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
Benjamin J. Thompson,Silvia Buonamici,Maria Luisa Sulis,Teresa Palomero,Tomas Vilimas,Giuseppe Basso,Adolfo A. Ferrando,Iannis Aifantis +7 more
TL;DR: The data suggest that FBW7 is a novel tumor suppressor in T cell leukemia, and implicate the loss ofFBW7 function as a potential mechanism of drug resistance in T-ALL.