N
Niles A. Pierce
Researcher at California Institute of Technology
Publications - 94
Citations - 14394
Niles A. Pierce is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Adjoint equation & Residual. The author has an hindex of 41, co-authored 92 publications receiving 12294 citations. Previous affiliations of Niles A. Pierce include University of Oxford.
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Journal ArticleDOI
Triggered amplification by hybridization chain reaction.
Robert M. Dirks,Niles A. Pierce +1 more
TL;DR: This work introduces the concept of hybridization chain reaction (HCR), in which stable DNA monomers assemble only upon exposure to a target DNA fragment, which allows DNA to act as an amplifying transducer for biosensing applications.
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Programming biomolecular self-assembly pathways
TL;DR: Diverse molecular self-assembly and disassembly pathways are program using a ‘reaction graph’ abstraction to specify complementarity relationships between modular domains in a versatile DNA hairpin motif.
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NUPACK: Analysis and design of nucleic acid systems
Joseph N. Zadeh,Conrad Steenberg,Justin S. Bois,Brian R. Wolfe,Marshall B. Pierce,Asif R. Khan,Robert M. Dirks,Niles A. Pierce +7 more
TL;DR: The Nucleic Acid Package (NUPACK) is a growing software suite for the analysis and design of nucleic acid systems and algorithms are formulated in terms ofucleic acid secondary structure.
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An Introduction to the Adjoint Approach to Design
Michael B. Giles,Niles A. Pierce +1 more
TL;DR: An introduction to the subject, emphasising the simplicity of the ideas when viewed in the context of linear algebra, and examples of the use of adjoint methods for optimising the design of business jets are presented.
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A synthetic DNA walker for molecular transport
Jong Shik Shin,Niles A. Pierce +1 more
TL;DR: A processive bipedal DNA walker powered by externally controlled DNA fuel strands is demonstrated, with real-time monitoring of specific bidirectional walker movement achieved via multiplexed fluorescence quenching.