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Nilsa Rivera-Del Valle
Researcher at University of Texas MD Anderson Cancer Center
Publications - 5
Citations - 1677
Nilsa Rivera-Del Valle is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Histone deacetylase & Vorinostat. The author has an hindex of 4, co-authored 5 publications receiving 1508 citations. Previous affiliations of Nilsa Rivera-Del Valle include University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Redox Regulation of Cell Survival
Dunyaporn Trachootham,Dunyaporn Trachootham,Dunyaporn Trachootham,Weiqin Lu,Marcia A. Ogasawara,Nilsa Rivera-Del Valle,Nilsa Rivera-Del Valle,Peng Huang +7 more
TL;DR: The current understanding of how disturbance in redox homeostasis may affect cell death and contribute to the development of diseases such as cancer and degenerative disorders is reviewed and the basic knowledge on redox regulation of cell survival can be used to develop strategies for the treatment or prevention of those diseases.
Journal ArticleDOI
Therapeutic Strategies to Enhance the Anticancer Efficacy of Histone Deacetylase Inhibitors
Claudia P. Miller,Claudia P. Miller,Melissa M. Singh,Nilsa Rivera-Del Valle,Nilsa Rivera-Del Valle,Christa A. Manton,Christa A. Manton,Joya Chandra +7 more
TL;DR: Several combination therapies are discussed, highlighting various epigenetic drugs, ROS-generating agents, proteasome inhibitors, and DNA-damaging compounds that together may provide a therapeutic advantage over single-agent strategies.
Journal ArticleDOI
PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells
Nilsa Rivera-Del Valle,Shan Gao,Shan Gao,Claudia P. Miller,Claudia P. Miller,Joy M. Fulbright,Joy M. Fulbright,Carolina Gonzales,Carolina Gonzales,Mint Sirisawad,Susanne M. Steggerda,Jennifer J. Wheler,Sriram Balasubramanian,Joya Chandra +13 more
TL;DR: Insight is provided into the mechanism of apoptosis induction by PCI-24781 in leukemia by highlighting the roles of caspase-8, FADD and increased superoxide levels.
Journal ArticleDOI
Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations
Nilsa Rivera-Del Valle,Tiewei Cheng,Mary E. Irwin,Hayley Donnella,Melissa M. Singh,Joya Chandra +5 more
TL;DR: A redox modulatory agent, adaphostin, enhances efficacy of two HDACi, vorinostat or ent inostat, but via different mechanisms indicating a point of divergence in the mechanisms of synergy between the two distinct HDACs and adap Hostin.