M
Marcia A. Ogasawara
Researcher at University of Texas MD Anderson Cancer Center
Publications - 20
Citations - 2877
Marcia A. Ogasawara is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Chronic lymphocytic leukemia & Mitochondrion. The author has an hindex of 15, co-authored 20 publications receiving 2543 citations. Previous affiliations of Marcia A. Ogasawara include University of Texas at Austin & New Mexico Institute of Mining and Technology.
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Journal ArticleDOI
Redox Regulation of Cell Survival
Dunyaporn Trachootham,Dunyaporn Trachootham,Dunyaporn Trachootham,Weiqin Lu,Marcia A. Ogasawara,Nilsa Rivera-Del Valle,Nilsa Rivera-Del Valle,Peng Huang +7 more
TL;DR: The current understanding of how disturbance in redox homeostasis may affect cell death and contribute to the development of diseases such as cancer and degenerative disorders is reviewed and the basic knowledge on redox regulation of cell survival can be used to develop strategies for the treatment or prevention of those diseases.
Journal ArticleDOI
K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis.
Yumin Hu,Weiqin Lu,Gang Chen,Peng Wang,Zhao Chen,Yan Zhou,Marcia A. Ogasawara,Dunyaporn Trachootham,Dunyaporn Trachootham,Li Feng,Helene Pelicano,Paul J. Chiao,Michael J. Keating,Guillermo Garcia-Manero,Peng Huang +14 more
TL;DR: This study suggests that induction of mitochondrial dysfunction is an important mechanism by which K-rasG12V causes metabolic changes and ROS stress in cancer cells, and promotes tumor development.
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Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells PREFERENCE FOR HYPOXIA AND HIGH DEPENDENCY ON GLYCOLYSIS
Yunfei Zhou,Yan Zhou,Takashi Shingu,Li Feng,Zhao Chen,Marcia A. Ogasawara,Michael J. Keating,Seiji Kondo,Peng Huang +8 more
TL;DR: This study suggests that stem-like cancer cells prefer a low oxygen microenvironment and actively utilize the glycolytic pathway for ATP generation, which may be an effective strategy to eradicate residual cancer stem cells that are otherwise resistant to chemotherapeutic agents in their hypoxic niches.
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Structural simplification of bioactive natural products with multicomponent synthesis. 2. Antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones
Igor V. Magedov,Igor V. Magedov,Madhuri Manpadi,Marcia A. Ogasawara,Adriana S. Dhawan,Snezna Rogelj,Severine Van slambrouck,Wim F.A. Steelant,Nikolai M. Evdokimov,Pavel Y. Uglinskii,Eerik M. Elias,Erica J. Knee,Paul Tongwa,Mikhail Yu. Antipin,Mikhail Yu. Antipin,Alexander Kornienko +15 more
TL;DR: These heterocyclic libraries are expected to provide promising new leads in anticancer drug design and display low nanomolar antiproliferative activity and induce apoptosis in human cancer cell lines.
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Small mitochondria-targeting molecules as anti-cancer agents.
TL;DR: The rationale and biological basis for developing mitochondrial-targeted compounds as potential anti-cancer agents are summarized, and key examples of small molecules that either directly impact mitochondria or functionally affect the metabolic alterations in cancer cells with mitochondrial dysfunction are provided.