Nilubon Singhto

TL;DR: Functional studies demonstrated that COM-treated exosomes enhanced monocyte and T-cell migration, monocyte activation and macrophage phagocytic activity, but on the other hand, reduced T- cell activation, and provided some implications to the immune response during kidney stone pathogenesis via exosomal pathway of macrophages after exposure to COM crystals.

TL;DR: Global protein network analysis demonstrated that altered proteins in cellular and secreted proteins extracted from PMA-treated cells (macrophages) were involved in cell death, lipid metabolism, cell morphology, cellular movement, and protein folding.

TL;DR: Functional investigations revealed that COM-treated exosomes enhanced IL-8 production from renal tubular cells, activated neutrophil migration, had increased (exosomal) membrane fragility, had greater binding capacity to COM crystals, and subsequently enhanced crystal invasion through extracellular matrix migration chamber.

TL;DR: A large data set of changes in proteomes of the hippocampus, brainstem and spinal cord in dogs naturally infected with rabies is reported for the first time, useful for better understanding of molecular mechanisms of rabies and for differentiation of its paralytic and furious forms.

TL;DR: The authors' extensive lipidome analyses of urinary microvesicles vs. exosomes provide potential lipidome markers to discriminate exosome from microvesicle and may lead to better understanding of EVs biogenesis.