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Nina Costantino
Researcher at Weizmann Institute of Science
Publications - 40
Citations - 4668
Nina Costantino is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Recombineering & Homologous recombination. The author has an hindex of 21, co-authored 37 publications receiving 4270 citations.
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Book ChapterDOI
Recombineering: using drug cassettes to knock out genes in vivo.
James A. Sawitzke,Lynn C. Thomason,Mikhail Bubunenko,Xintian Li,Nina Costantino,Donald L. Court +5 more
TL;DR: Recombineering provides a new way to generate knockout mutations directly on the bacterial chromosome or to modify any plasmid or BAC in vivo as a prelude to making knockouts in other organisms.
Journal ArticleDOI
The alpha subunit of RNA polymerase and transcription antitermination
A. T. Schauer,Sheau Wei C. Cheng,Chuanhai Zheng,Chuanhai Zheng,Linda St. Pierre,Diane M. Alessi,Debra L. Hidayetoglu,Nina Costantino,Donald L. Court,David I. Friedman +9 more
TL;DR: The isolation and characterization of the rpoAD305E mutation is reported, a single amino acid change in the carboxy terminal domain (CTD) of the α subunit of RNA polymerase, that enhances N‐mediated antitermination and suppresses the effect of nus mutations.
A Proteomic and Transcriptomic Approach Reveals New Insight into - methylthiolation of Escherichia coli Ribosomal Protein S12 Running Title: Characterization of Ribosomal S12 PTM
Michael Brad Strader,Nina Costantino,Christopher A. Elkins,Cai Yun Chen,Isha R. Patel,Anthony J. Makusky,John S. Choy,Donald L. Court,Jeffrey A. Kowalak +8 more
E. coli Genome Manipulation by P1
TL;DR: This unit describes the procedure used to move portions of the E. coli genome from one genetic variant to another, and the resulting phage lysate is used to infect a second recipient strain.
Journal ArticleDOI
A coordinated proteomic approach for identifying proteins that interact with the E. coli ribosomal protein S12.
Michael Brad Strader,William Judson Hervey,Nina Costantino,Suwako Fujigaki,Cai Yun Chen,Ayca Akal-Strader,Chibueze A. Ihunnah,Anthony J. Makusky,Donald L. Court,Sanford P. Markey,Jeffrey A. Kowalak +10 more
TL;DR: Evidence that two proteins involved in regulating ribosome and/or mRNA transcript levels under stress conditions, RNase R and Hfq, form direct interactions with the S12 conserved loop, suggesting that it is likely part of a protein binding interface is provided.