D
David I. Friedman
Researcher at University of Michigan
Publications - 89
Citations - 6096
David I. Friedman is an academic researcher from University of Michigan. The author has contributed to research in topics: Gene & Antitermination. The author has an hindex of 45, co-authored 89 publications receiving 5896 citations. Previous affiliations of David I. Friedman include Walter Reed Army Institute of Research.
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Journal ArticleDOI
Integration host factor: a protein for all reasons.
TL;DR: The identification and characterization of the Escherichia coli DNA binding protein integration host factor (IHF) is an elegant example of how a well-characterized virus can be employed in the analysis of a host function.
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Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing
Gang Fang,Diana Munera,Diana Munera,David I. Friedman,Anjali Mandlik,Anjali Mandlik,Michael C. Chao,Michael C. Chao,Onureena Banerjee,Zhixing Feng,Zhixing Feng,Bojan Losic,Milind Mahajan,Omar Jabado,Gintaras Deikus,Tyson A. Clark,Khai Luong,Iain A. Murray,Brigid M. Davis,Brigid M. Davis,Alona Keren-Paz,Andrew Chess,Richard J. Roberts,Jonas Korlach,Steve W. Turner,Vipin Kumar,Matthew K. Waldor,Matthew K. Waldor,Eric E. Schadt +28 more
TL;DR: It is found that deletion of a phage-encoded methyltransferase-endonuclease (restriction-modification; RM) system induced global transcriptional changes and led to gene amplification, suggesting that the role of RM systems extends beyond protecting host genomes from foreign DNA.
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Role for a phage promoter in Shiga toxin 2 expression from a pathogenic Escherichia coli strain.
Patrick L. Wagner,Melody N. Neely,Xiaoping Zhang,David W. K. Acheson,Matthew K. Waldor,Matthew K. Waldor,David I. Friedman +6 more
TL;DR: Since transcription initiating at p(R') ultimately requires activation of the phage lytic cascade, expression of stx(2)AB in STEC depends primarily on prophage induction, contradict the prevailing assumption that phages serve merely as agents for virulence gene transfer.
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Functional and genetic analysis of regulatory regions of coliphage H-19B: location of shiga-like toxin and lysis genes suggest a role for phage functions in toxin release
TL;DR: Observations suggest that stx‐I expression can be enhanced by transcription from pR′ as a model for toxin release through cell lysis mediated by action of phage‐encoded lysis functions.
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Bacteriophage control of Shiga toxin 1 production and release by Escherichia coli
Patrick L. Wagner,Jonathan Livny,Melody N. Neely,David W. K. Acheson,David I. Friedman,Matthew K. Waldor,Matthew K. Waldor +6 more
TL;DR: It is found that replication of the phage genome, with the associated increase in stx1AB copy number, is the most quantitatively important mechanism by which H‐19B induction increases Stx1 production.