Nina Ebel

TL;DR: High hydrostatic pressure offers both, an economic, easy to apply, clean, and fast technique for the generation of vaccines, and a promising tool to study physiological aspects of pressure on eukaryotic cells.

TL;DR: The complete tumor cell inactivation, the degradation of the cell’s nuclei, and the retention of the immunogeneic potential of these dead tumor cells induced by HHP favor the use of this technique as a powerful and low-cost technique for the inactivation of tumor cells to be used as a vaccine.

TL;DR: It is demonstrated that conventional absorption spectroscopy in the ultraviolet, visible and near-infrared spectral range facilitates characterization of Escherichia coli (E. coli) suspensions and provides a tool for the investigation of the inactivation mechanisms.

TL;DR: High hydrostatic pressure (HHP) is introduced as an innovative inactivation technology for tumor cell-based vaccines and studies are presented proving that anti-tumor immune responses can be triggered by combining RT with selected immune therapies.

TL;DR: It is shown for the first time that tumor cell-based vaccine acts synergistically with RTx to significantly retard tumor growth by generating a favorable anti-tumor immune microenvironment.