Nina Kosaric

TL;DR: It is shown that changes in the microenvironment including alterations in mechanical forces, oxygen levels, chemokines, extracellular matrix and growth factor synthesis directly impact cellular recruitment and activation, leading to impaired states of wound healing.

TL;DR: The data suggest that injectable PEG–gelatin hydrogel can be used for regulating stem cell behaviors in 3D culture, delivering cells for wound healing and other tissue regeneration applications.

TL;DR: This review provides an overview of wound healing and current methods for the management of chronic wounds, as well as the current state and considerations for optimizing stem cell therapy, which have been shown to accelerate wound healing by modulating the immune response and promoting angiogenesis.

TL;DR: Otic induction follows the predicted dynamics of gene expression and resembles otic cells from native mouse tissue up to 12 days of culture, and single-cell trajectory analysis revealed that otic progenitor cell types are induced in monolayer cultures, but further development appears impeded, likely because of lack of a lineage-stabilizing microenvironment.

TL;DR: It is found that BM‐MSCs from young donors healed wounds in a xenograft model faster compared with their aged counterparts (p < .001), and single‐cell transcriptomic analysis was used to provide potential molecular insights into these observations.