Y
Yongsheng Gao
Researcher at Harvard University
Publications - 58
Citations - 2283
Yongsheng Gao is an academic researcher from Harvard University. The author has contributed to research in topics: Gene delivery & Self-healing hydrogels. The author has an hindex of 21, co-authored 58 publications receiving 1429 citations. Previous affiliations of Yongsheng Gao include Katholieke Universiteit Leuven & Tianjin University.
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Journal ArticleDOI
Injectable and Tunable Gelatin Hydrogels Enhance Stem Cell Retention and Improve Cutaneous Wound Healing
Yixiao Dong,Yixiao Dong,Sigen A,Melanie Rodrigues,Xiaolin Li,Sun H. Kwon,Nina Kosaric,Sacha M.L. Khong,Yongsheng Gao,Wenxin Wang,Geoffrey C. Gurtner +10 more
TL;DR: The data suggest that injectable PEG–gelatin hydrogel can be used for regulating stem cell behaviors in 3D culture, delivering cells for wound healing and other tissue regeneration applications.
Journal ArticleDOI
A hybrid injectable hydrogel from hyperbranched PEG macromer as a stem cell delivery and retention platform for diabetic wound healing.
Qian Xu,Sigen A,Yongsheng Gao,Linru Guo,Jack Creagh-Flynn,Dezhong Zhou,Udo Greiser,Yixiao Dong,Fagang Wang,Hongyun Tai,Wenguang Liu,Wei Wang,Wenxin Wang +12 more
TL;DR: A new injectable hydrogel system was fabricated from hyperbranched multi-acrylated poly(ethylene glycol) macromers (HP-PEGs) and thiolated hyaluronic acid (HA-SH) and used as a stem cell delivery and retention platform and may be a promising candidate for diabetic wound treatment.
Journal ArticleDOI
The transition from linear to highly branched poly(β-amino ester)s: Branching matters for gene delivery
Dezhong Zhou,Dezhong Zhou,Lara Cutlar,Yongsheng Gao,Wei Wang,Jonathan O'Keeffe-Ahern,Sean McMahon,Blanca Duarte,Fernando Larcher,Brian J. Rodriguez,Udo Greiser,Wenxin Wang,Wenxin Wang +12 more
TL;DR: The findings prove that the A2 + B3 + C2 approach is highly generalizable and flexible for the design and synthesis of HPAEs, which cannot be achieved by the conventional polymerization approach; H PAEs are more efficient vectors in gene transfection than the corresponding LPAEs.
Journal ArticleDOI
Injectable hyperbranched poly(β-amino ester) hydrogels with on-demand degradation profiles to match wound healing processes
Qian Xu,Linru Guo,Sigen A,Yongsheng Gao,Dezhong Zhou,Udo Greiser,Jack Creagh-Flynn,Hong Zhang,Yixiao Dong,Lara Cutlar,Fagang Wang,Wenguang Liu,Wei Wang,Wei Wang,Wenxin Wang,Wenxin Wang +15 more
TL;DR: A series of hyperbranched poly(β-amino ester) polymers have been synthesized via a Michael addition approach for the fabrication of hydrogels for wound healing.
Journal ArticleDOI
Highly branched poly(β-amino ester)s for skin gene therapy.
Dezhong Zhou,Yongsheng Gao,Ahmed Aied,Lara Cutlar,Olga Igoucheva,Ben Newland,Vitali Alexeeve,Udo Greiser,Jouni Uitto,Wenxin Wang,Wenxin Wang +10 more
TL;DR: The development of highly branched poly(β-amino ester)s (HPAEs) via a new "A2+B3+C2" Michael addition approach demonstrating 2 to 126-fold higher in vitro transfection efficiencies of different cell types in comparison to their linear LPAE counterparts as well as greatly out-performing the leading transfections reagents SuperFect and the "gold-standard" polyethyleneimine (PEI).